D2064
Dequalinium analog, C-14 Linker
别名:
1,1′-(1,14-Tetradecanediyl)bis[4-amino-2-methylquinollinium] diiodide, 1,1′-(1,14-tetradecanediyl) bis diiodide, C14 Linker, DECA-14, Dequalinium analog, Dequalinium-14, Quinolinium
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关于此项目
经验公式（希尔记法）:
C34H48N4I2
化学文摘社编号:
分子量:
766.58
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
InChI
1S/C34H46N4.2HI/c1-27-25-31(35)29-19-13-15-21-33(29)37(27)23-17-11-9-7-5-3-4-6-8-10-12-18-24-38-28(2)26-32(36)30-20-14-16-22-34(30)38;;/h13-16,19-22,25-26,35-36H,3-12,17-18,23-24H2,1-2H3;2*1H
InChI key
RBXJPYMCKQMUHW-UHFFFAOYSA-N
assay
94% (HPLC)
form
solid
color
light brown
mp
258-260 °C
solubility
DMSO: soluble
storage temp.
−20°C
Gene Information
human ... PRKCA(5578)
Biochem/physiol Actions
Protein kinase Cα (PKCα) inhibitor; antitumor agent.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
此项目有
R M Sullivan et al.
Molecular pharmacology, 58(4), 729-737 (2000-09-22)
Dequalinium (DECA) is a potent antitumor agent and inhibitor of protein kinase C (PKC). Previously it was shown that PKCalpha activity in vitro could be irreversibly inhibited when treated with DECA at low micromolar concentrations and irradiated with 366 nm
Christopher H Miller et al.
Antimicrobial agents and chemotherapy, 53(12), 5279-5283 (2009-09-30)
In this study, application of a dual absorbance/fluorescence assay to a chemical library screen identified several previously unknown inhibitors of mycobacteria. In addition, growth conditions had a significant effect on the activity profile of the library. Some inhibitors such as
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