D2696
去氢木香内酯
≥98% (HPLC)
别名:
(−)-脱氢肋内酯；脱氢肋内酯;环氧丙烷脱氢肋内酯, Guaia-4（15），10（14），11（13）-三烯-12-油酸，6α-羟基-，γ-内酯, [3aS-(3aα,6aα,9aα,9bβ)]-十氢-3,6,9-三（亚甲基）-薁并[4,5-b ]呋喃-2（3H）-酮, 脱氢肋内酯（6CI，7CI）, 脱氢肋骨内酯, （3aS，6aR，9aR，9bS）-十氢-3,6,9-三（亚甲基）-薁并[4,5-b]呋喃-2（3H）-酮
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关于此项目
经验公式（希尔记法）:
C15H18O2
化学文摘社编号:
分子量:
230.30
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
assay
≥98% (HPLC)
form
powder
color
white to off-white
solubility
DMSO: ≥20 mg/mL
storage temp.
room temp
SMILES string
C=C1CC[C@@]2([H])C(CC[C@@H]3[C@H](OC(C3=C)=O)[C@]21[H])=C
InChI
1S/C15H18O2/c1-8-4-7-12-10(3)15(16)17-14(12)13-9(2)5-6-11(8)13/h11-14H,1-7H2/t11-,12-,13-,14-/m0/s1
InChI key
NETSQGRTUNRXEO-XUXIUFHCSA-N
Biochem/physiol Actions
去氢木香内酯（DHE）是从雪莲和木香中提取的倍半萜内酯。该化合物具有抗真菌和抗分枝杆菌活性，并显示出对 HepG2、OVCAR-3 和 HeLa 细胞系的细胞毒性作用。
细胞因子信号传导（SOCS）蛋白的抑制因子负调节细胞因子受体信号传导。SOCS 系列包括 8 个成员，即 SOCS-1 至 SOCS-7 和 CIS。去氢木香内酯（DHE）是从雪莲和木香中提取的倍半萜内酯。该化合物具有抗真菌和抗分枝杆菌活性，并显示出对 HepG2、OVCAR-3 和 HeLa 细胞系的细胞毒性作用。DHE 不仅可以抑制早期乳腺癌 MCF-7 中的细胞增殖，还可以抑制更晚期 MDA-MB-231 癌细胞中的细胞增殖，而对 H184B5F5/M10 正常乳腺上皮细胞没有明显影响。对乳腺癌细胞增殖的抑制是通过细胞周期阻滞和凋亡发生的。 DHE 通过 SOCS-1 和 SOCS-3 抑制细胞周期进程和细胞死亡。
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signalword
Warning
hcodes
Hazard Classifications
Skin Sens. 1
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
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Dan Wang et al.
Journal of Asian natural products research, 11(12), 991-996 (2010-02-26)
Aspergillus versicolor D-1 was employed to convert dehydrocostuslactone (1) and 3-hydroxy-1(10),3,11(13)-guaiatriene-12,6-olide-2-one (5) stereoselectively. The reactions occurring were specific hydrogenation on the exocyclic alpha,beta-double bond of sesquiterpene lactones with excellent conversion. Products were identified by the analysis of their spectra such
Xiao-ping Zhao et al.
Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences, 41(1), 43-46 (2012-03-16)
To screen the potential hepatotoxic components in Chinese herb medicine Aucklandiae Radix. The potential hepatotoxic components were screened using HepG2 cells labeled with fluorescein diacetate from 25 fractions of Aucklandiae Radix, in which the hepatotoxic compounds were further identified with
Chih-Ya Wang et al.
PloS one, 7(2), e31195-e31195 (2012-02-24)
The traditional Chinese medicine component dehydrocostuslactone (DHC) isolated from Saussurea costus (Falc.) Lipschitz, has been shown to have anti-cancer activity. Angiogenesis is an essential process in the growth and progression of cancer. In this study, we demonstrated, for the first
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| D2696-25MG | 04061832644844 |
| D2696-5MG | 04061832644851 |