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Merck
CN

D2889

Sigma-Aldrich

1,3-Dimethyluric acid

别名:

1,3-Dimethyl-2,6,8-trihydroxypurine, 1,3-Dimethyl-7,9-dihydro-1H-purine-2,6,8(3H)-trione, Oxytheophylline

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关于此项目

经验公式(希尔记法):
C7H8N4O3
化学文摘社编号:
分子量:
196.16
Beilstein:
193698
EC 号:
MDL编号:
UNSPSC代码:
41106305
PubChem化学物质编号:
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方案

≥98% (TLC)

表单

powder

mp

≥300 °C (lit.)

溶解性

1 M NH4OH: soluble 50 mg/mL, clear to slightly hazy, colorless to faintly yellow

储存温度

−20°C

SMILES字符串

CN1C(=O)N(C)C2=C(NC(=O)N2)C1=O

InChI

1S/C7H8N4O3/c1-10-4-3(8-6(13)9-4)5(12)11(2)7(10)14/h1-2H3,(H2,8,9,13)

InChI key

OTSBKHHWSQYEHK-UHFFFAOYSA-N

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储存分类代码

13 - Non Combustible Solids

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

新产品
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Yu Chul Kim et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 26(1), 114-123 (2005-06-30)
Pharmacokinetic parameters of theophylline and one of its metabolites, 1,3-dimethyluric acid (1,3-DMU), were compared after intravenous and oral administration of aminophylline, 5mg/kg as theophylline, to diabetes mellitus rats induced by alloxan (DMIA) or streptozotocin (DMIS), and their respective control rats.
Y Mizuki et al.
Antimicrobial agents and chemotherapy, 40(8), 1875-1880 (1996-08-01)
Enoxacin, an antimicrobial fluoroquinolone with a 7-piperazinyl-1, 8-naphthyridine skeleton, is a potent inhibitor of cytochrome P-450-mediated theophylline metabolism. The present study was designed to clarify, using seven enoxacin derivatives, the molecular characteristics of the fluoroquinolone responsible for the inhibition. Three
Andreas Daiber et al.
International journal of molecular sciences, 14(4), 7542-7570 (2013-04-10)
The reaction product of nitric oxide and superoxide, peroxynitrite, is a potent biological oxidant. The most important oxidative protein modifications described for peroxynitrite are cysteine-thiol oxidation and tyrosine nitration. We have previously demonstrated that intrinsic heme-thiolate (P450)-dependent enzymatic catalysis increases
Eun Jung Kim et al.
Life sciences, 72(11), 1231-1245 (2003-02-07)
It was obtained from our laboratories that the expression of hepatic microsomal cytochrome P450 (CYP) 1A2 increased approximately 3.5 times in mutant Nagase analbuminemic rats (NARs, an animal model for human familial analbuminemia), and theophylline was reported to be metabolized
Su Yeon Yu et al.
The Journal of pharmacy and pharmacology, 54(12), 1687-1692 (2003-01-25)
In rats with acute renal failure induced by uranyl nitrate, the hepatic microsomal cytochrome P450 (CYP) 2E1 and CYP3A23 increased 2-4- and 4-times, respectively, CYP2C11 decreased to 80% of control, but the levels of CYP1A2 and CYP2B1/2 were not changed.

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