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Merck
CN

D3938

Anti-DR5 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

别名:

Anti-Death Receptor 5, Anti-KILLER, Anti-TRAIL-R2, Anti-TRICK2

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关于此项目

UNSPSC Code:
12352203
MDL number:
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ARR, WB
Citations:
6
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biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 57 kDa

species reactivity

human

technique(s)

microarray: suitable, western blot: 2 μg/mL using human HeLa and K562 cell extracts

UniProt accession no.

shipped in

dry ice

storage temp.

−20°C

Gene Information

human ... TNFRSF10B(8795)

General description

DR5 is a death domain-containing receptor that is activated through a p53-depedent pathway in response to radiation and DNA damage . DR5 is involved in caspase activation and cell apoptosis . Anti-DR5 antibody is specific for DR5 in humans.

Immunogen

synthetic peptide corresponding to amino acids 388-407 of the human DR5 precursor.

Application

Anti-DR5 antibody may be used in western blot (1 μg/mL using human HeLa and K562 cell extracts), immunoblot and microarray.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.


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存储类别

12 - Non Combustible Liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

常规特殊物品

此项目有



历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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相关内容


Zhongfan Deng et al.
PloS one, 7(5), e37700-e37700 (2012-06-05)
Hepatitis C virus (HCV) is the leading cause of liver fibrosis, cirrhosis and hepatocellular carcinoma. It is believed that continuous liver cell apoptosis contributes to HCV pathogenesis. Recent studies have shown that HCV infection can sensitize host cells to TNF-related
G S Wu et al.
Advances in experimental medicine and biology, 465, 143-151 (2000-05-16)
TRAIL and its emerging receptors are the newest members of the TNF receptor super-family. The activation of TRAIL receptors by ligand binding leads to apoptosis through caspase activation through an as yet unclear signaling pathway that does not require the
R Takimoto et al.
Oncogene, 19(14), 1735-1743 (2000-04-25)
KILLER/DR5, a tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) death receptor gene, has been shown to be induced by DNA damaging agents and radiation in a p53-dependent manner. Although TRAIL is a potential therapeutic agent for cancer, the induction mechanism of



全球贸易项目编号

货号GTIN
D3938-.1MG04061833619513