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Merck
CN

D4072

Delta Sleep Inducing Peptide

别名:

DSIP, Emideltide, Sleep inducing peptide, Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu

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关于此项目

经验公式（希尔记法）:
C35H48N10O15
化学文摘社编号:
62568-57-4
分子量:
848.81
NACRES:
NA.32
PubChem Substance ID:
329798794
UNSPSC Code:
12352200
MDL number:
MFCD00076883

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InChI key

ZRZROXNBKJAOKB-GFVHOAGBSA-N

SMILES string

C[C@H](NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(=O)NCC(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(O)=O

InChI

1S/C35H48N10O15/c1-16(41-32(56)20(36)9-18-11-37-21-6-4-3-5-19(18)21)30(54)39-12-25(47)38-13-26(48)44-23(10-29(52)53)34(58)42-17(2)31(55)45-24(15-46)33(57)40-14-27(49)43-22(35(59)60)7-8-28(50)51/h3-6,11,16-17,20,22-24,37,46H,7-10,12-15,36H2,1-2H3,(H,38,47)(H,39,54)(H,40,57)(H,41,56)(H,42,58)(H,43,49)(H,44,48)(H,45,55)(H,50,51)(H,52,53)(H,59,60)/t16-,17-,20-,22-,23-,24-/m0/s1

form

powder

storage temp.

−20°C

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Biochem/physiol Actions

DSIP promotes sleep by targeting various areas of the brain. The peptide is easily absorbed from the gut and is not denatured by enzymes. It crosses the blood-brain barrier easily. DSIP influences the circadian rhythm in humans. Low concentrations of the peptide are observed in patients with schizophrenia and depression.

General description

Delta sleep inducing peptide (DSIP) is a nonapeptide which was isolated from the rabbit brain. It is synthesized in the hypothalamus and is present in small amounts in the blood.

存储类别

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

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分析证书(COA)

Lot/Batch Number
SLBK6326
SLBK6162

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Delta sleep-inducing peptide
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European Journal of Anaesthesiology, 18(7), 419-422 (2001)
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Journal of mass spectrometry : JMS, 54(6), 481-487 (2019-03-09)
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