D4899
Dynorphin A Porcine Fragment 1-8
≥97% (HPLC)
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关于此项目
经验公式（希尔记法）:
C46H72N14O10
化学文摘社编号:
分子量:
981.15
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
SMILES string
CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc2ccc(O)cc2)C(O)=O
assay
≥97% (HPLC)
composition
Peptide content, ~70%
storage temp.
−20°C
Gene Information
human ... OPRD1(4985), OPRK1(4986), OPRM1(4988)
pig ... PDYN(445529)
rat ... Oprd1(24613), Oprm1(25601)
Biochem/physiol Actions
Potent κ opioid agonist; its agonist activity at μ and δ receptors may be due to hydrolysis of the peptide by proteases in the membrane or cell preparations.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
Yu Zhang et al.
The International journal of neuroscience, 115(7), 935-948 (2005-07-30)
The formalin test was used to elicit acute and chronic pain in rats, and antisense oligodeoxynucleotide (AS-ODN) was used as a tool to modulate the expression of nociceptive behavioral and neurochemical responses. AS-ODN complementary to c-Fos mRNA was administered intrathecally
K Kitamura et al.
Naunyn-Schmiedeberg's archives of pharmacology, 361(3), 273-278 (2000-03-24)
Previous in vitro studies showed that the degradation of dynorphin-(1-8) [dyn-(1-8)] by cerebral membrane preparations is almost completely prevented by a mixture of three peptidase inhibitors (PIs), amastatin, captopril and phosphoramidon. In the present investigations, effects of the three PIs
L Prokai et al.
Rapid communications in mass spectrometry : RCM, 12(22), 1796-1800 (1998-12-16)
Synaptic metabolism of the endogenous opioid octapeptide dynorphin (Dyn) A (1-8) (Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile) was studied in vitro upon its incubation with synaptosomes and with synaptosomal plasma membranes isolated from rat brain tissue. Electrospray ionization (ESI) and tandem mass spectromety were performed
Peter W Marinelli et al.
Alcoholism, clinical and experimental research, 30(6), 982-990 (2006-06-02)
Pharmacological studies have implicated the endogenous opioid system in mediating alcohol intake. Other evidence has shown that alcohol administration can influence endorphinergic and enkephalinergic activity, while very few studies have examined its effect on dynorphinergic systems. The aim of the
T Hiranuma et al.
The Journal of pharmacology and experimental therapeutics, 286(2), 863-869 (1998-08-08)
The amounts of dynorphin-(1-8) [dyn-(1-8)] and its seven hydrolysis products, Y, YG, YGG, YGGF, YGGFL, YGGFLR and YGGFLRR, were estimated after incubating dyn-(1-8) with a membrane fraction from either guinea-pig ileum or striatum for various times at 37 degrees C.
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