D4899
Dynorphin A Porcine Fragment 1-8
≥97% (HPLC)
方案
≥97% (HPLC)
组成
Peptide content, ~70%
储存温度
−20°C
SMILES字符串
CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc2ccc(O)cc2)C(O)=O
基因信息
human ... OPRD1(4985), OPRK1(4986), OPRM1(4988)
pig ... PDYN(445529)
rat ... Oprd1(24613), Oprm1(25601)
Amino Acid Sequence
Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile
生化/生理作用
Potent κ opioid agonist; its agonist activity at μ and δ receptors may be due to hydrolysis of the peptide by proteases in the membrane or cell preparations.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
Sébastien Ballet et al.
Journal of neurochemistry, 81(3), 659-662 (2002-06-18)
Intrathecal infusion of the neuropeptide FF analogue, [D-Tyr1, (NMe)Phe3]neuropeptide FF (1DMe; 0.1 microm-0.1 mm) in anaesthetized rats produced a concentration-dependent decrease in the spinal outflow of dynorphin A (1-8)-like material, which persisted for at least 90 min after treatment with
H Wenzlaff et al.
Naunyn-Schmiedeberg's archives of pharmacology, 358(3), 360-366 (1998-10-17)
Opioids directly decrease the contractile response of isolated ventricular cardiomyocytes to electrical stimulation. To investigate whether these effects are mediated via GTP-binding G(i/o) proteins we examined the influence of pertussis toxin on the effects of the kappa-opioid receptor agonist trans-(+/-)-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl)-cyclohexyl]-benz
Samuel Jarjour et al.
Alcoholism, clinical and experimental research, 33(6), 1033-1043 (2009-03-24)
Experimental evidence suggests that ethanol alters the activity of the endogenous opioid peptide systems in a dose and brain-region dependent manner. These alterations may influence the processes of ethanol reward and reinforcement. Thus, it was the objective of this study
Qiang Zhang et al.
Endocrine, 18(1), 27-32 (2002-08-09)
The objective of this study was to determine whether prodynorphin-derived opioid peptides could block the spontaneous luteinizing hormone (LH) surge and ovulation, and if so, whether this inhibitory action was mediated through kappa-opioid receptors. Various doses of dynorphin peptides (dynorphin
G Ronsisvalle et al.
Journal of medicinal chemistry, 43(16), 2992-3004 (2000-08-24)
Two novel series of kappa opioid receptor agonist analogues of MPCB-GRRI and MPCB-RRI, hybrid ligands of MPCB ((-)-cis-N-(2-phenyl-2-carbomethoxy)cyclopropylmethyl-N-normetazocine ) and of the C-terminal fragments of dynorphin A(1-8), have been synthesized. The critical functional groups of the peptide fragments of hybrid
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