D5011
5′-脱氧-5′-腺苷
≥98% (HPLC), synthetic (organic), powder
别名:
甲硫腺苷, MTA
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经验公式（希尔记法）:
C11H15N5O3S
化学文摘社编号:
分子量:
297.33
NACRES:
NA.51
PubChem Substance ID:
UNSPSC Code:
41106305
MDL number:
Beilstein/REAXYS Number:
42420
产品名称
5′-脱氧-5′-腺苷,
InChI
1S/C11H15N5O3S/c1-20-2-5-7(17)8(18)11(19-5)16-4-15-6-9(12)13-3-14-10(6)16/h3-5,7-8,11,17-18H,2H2,1H3,(H2,12,13,14)/t5-,7-,8-,11-/m1/s1
SMILES string
CSC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n2cnc3c(N)ncnc23
InChI key
WUUGFSXJNOTRMR-IOSLPCCCSA-N
biological source
synthetic (organic)
assay
≥98% (HPLC)
form
powder
solubility
DMF: 50 mg/mL, clear to very slightly hazy, colorless to faintly yellow
storage temp.
−20°C
Quality Level
Gene Information
human ... ADORA2B(136), ADORA3(140)
mouse ... Mtap(66902)
rat ... Adora1(29290), Adora2a(25369)
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Application
5′-脱氧-5′-(甲硫基)腺苷已被用作蛋白质甲基化抑制剂，可降低肝细胞癌(HCC)细胞中的E2F转录因子1（E2F1）蛋白丰度。这种成分还用于抑制组蛋白甲基化修饰，研究其在缺氧诱导因子1(Hif-1)核转运中的作用。
Biochem/physiol Actions
5′-脱氧-5′-（甲硫基）腺苷（甲硫腺苷）可用作底物来研究5′-甲硫腺苷磷酸化酶（MTAP）（EC2.4.2.28）的特异性和动力学，该酶是一个肿瘤抑制基因所表达的酶，其可支持S-腺苷甲硫氨酸（AdoMet）和蛋氨酸补救途径。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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