D5816
(−)-Depudecin
>95% (HPLC), from microbial
别名:
4,5:8,9-Dianhydro-1,2,6,7,11-pentadeoxy-D-threo-D-ido-undeca-1,6-dienitol
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关于此项目
经验公式（希尔记法）:
C11H16O4
化学文摘社编号:
分子量:
212.24
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
biological source
microbial
assay
>95% (HPLC)
form
liquid
shipped in
dry ice
storage temp.
−20°C
SMILES string
C[C@@H](O)[C@@H]1O[C@H]1\C=C\[C@@H]2O[C@H]2[C@H](O)C=C
InChI
1S/C11H16O4/c1-3-7(13)11-9(15-11)5-4-8-10(14-8)6(2)12/h3-13H,1H2,2H3/b5-4+/t6-,7-,8+,9+,10+,11+/m1/s1
InChI key
DLVJMFOLJOOWFS-INMLLLKOSA-N
Biochem/physiol Actions
Inhibitor of histone deacetylase (HDAC) both in vivo and in vitro. Alters the spindle shaped morphology of v-Ha-ras-transformed NIH3T3 cells to a flattened shape and induces an intricate actin stress fiber network in these cells and in MG63 osteosarcoma cells. Also exhibits anti-angiogenic activity.
Inhibitor of histone deacetylase (HDAC) both in vivo and in vitro; exhibits anti-angiogenic activity.
Features and Benefits
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存储类别
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
K Sugita et al.
Biochemical and biophysical research communications, 182(1), 379-387 (1992-01-15)
A novel compound, depudecin, induced production of the flat phenotype of Ki-ras-transformed NIH3T3 cells at the low concentration of 1 microgram/ml. This effect was reversible. Actin stress fiber was detected in these cells after depudecin treatment. Almost complete reversion to
Wanessa D Wight et al.
Molecular plant-microbe interactions : MPMI, 22(10), 1258-1267 (2009-09-10)
Depudecin, an eleven-carbon linear polyketide made by the pathogenic fungus Alternaria brassicicola, is an inhibitor of histone deacetylase (HDAC). A chemically unrelated HDAC inhibitor, HC toxin, was earlier shown to be a major virulence factor in the interaction between Cochliobolus
M Tanaka et al.
Bioscience, biotechnology, and biochemistry, 64(2), 244-247 (2000-03-29)
Feeding experiments of labeled acetates to Nimbya scirpicola proved the carbon origin of the straight-chain polyketide, depudecin. Differential hydrogen exchange of the 2H label originating from 2H labeled acetate along the polyketide chain occurred. In particular, the deuterium of an