D5891
1,1-二甲基-4-苯基哌嗪碘化物
≥98% (TLC or titration)
别名:
DMPP
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关于此项目
经验公式（希尔记法）:
C12H19IN2
化学文摘社编号:
分子量:
318.20
UNSPSC Code:
12352200
NACRES:
NA.77
PubChem Substance ID:
EC Number:
200-213-0
Beilstein/REAXYS Number:
3746109
MDL number:
Assay:
≥98% (TLC or titration)
Form:
powder
assay
≥98% (TLC or titration)
form
powder
mp
234-238 °C (lit.)
solubility
H2O: 21 mg/mL
storage temp.
−20°C
SMILES string
[I-].C[N+]1(C)CCN(CC1)c2ccccc2
InChI
1S/C12H19N2.HI/c1-14(2)10-8-13(9-11-14)12-6-4-3-5-7-12;/h3-7H,8-11H2,1-2H3;1H/q+1;/p-1
InChI key
XFZJGFIKQCCLGK-UHFFFAOYSA-M
Gene Information
Application
1,1-Dimethyl-4-phenylpiperazinium iodide (DMPP) has been used as a non-selective nicotinic acetylcholine receptor (nAchR) agonist:
- to study the roles of α7 and α4β2 nAchRs in autonomic regulation of cardiovascular responses in urethane-anesthetized mice
- to study the mechanism involved in improving glucose tolerance in diet-induced obese (DIO) mice treated with DMPP
- to study its pharmacological effect on enteric viscerofugal neurons in the myenteric plexus of guinea-pig colon
Biochem/physiol Actions
1,1-Dimethyl-4-phenylpiperazinium iodide (DMPP) is a non-selective nicotinic acetylcholine receptor (nAchR) agonist. It acts as a stimulating agent for sympathetic ganglia. DMPP exhibits specific action on ganglia and adrenal medullary tissue hence, it finds its application in the diagnosis of pheochromocytoma.
Features and Benefits
This compound is featured on the Acetylcholine Receptors (Nicotinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
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存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| D5891-1G | 04061825982212 |
| D5891-10G | 04061832090528 |