Name: 1,1-二甲基-4-苯基哌嗪碘化物
Brand: SIGMA

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About This Item

经验公式（希尔记法）:

C₁₂H₁₉IN₂

CAS Number:

54-77-3

分子量:

318.20

Beilstein:

3746109

EC 号:

200-213-0

MDL编号:

MFCD00011976

UNSPSC代码:

12352200

PubChem化学物质编号:

24277832

NACRES:

NA.77

技术服务

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方案

≥98% (TLC or titration)

表单

powder

mp

234-238 °C (lit.)

溶解性

H₂O: 21 mg/mL

储存温度

−20°C

SMILES字符串

[I-].C[N+]1(C)CCN(CC1)c2ccccc2

InChI

1S/C12H19N2.HI/c1-14(2)10-8-13(9-11-14)12-6-4-3-5-7-12;/h3-7H,8-11H2,1-2H3;1H/q+1;/p-1

InChI key

XFZJGFIKQCCLGK-UHFFFAOYSA-M

基因信息

human ... CHRNA1(1134), CHRNA10(57053), CHRNA2(1135), CHRNA3(1136), CHRNA4(1137), CHRNA5(1138), CHRNA6(8973), CHRNA7(1139), CHRNA9(55584), CHRNB1(1140), CHRNB2(1141), CHRNB3(1142), CHRNB4(1143)
rat ... Chrna2(170945), Chrna3(25101), Chrna4(25590), Chrnb2(54239), Chrnb4(25103)

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应用

1,1-Dimethyl-4-phenylpiperazinium iodide (DMPP) has been used as a non-selective nicotinic acetylcholine receptor (nAchR) agonist:

to study the roles of α7 and α4β2 nAchRs in autonomic regulation of cardiovascular responses in urethane-anesthetized mice
to study the mechanism involved in improving glucose tolerance in diet-induced obese (DIO) mice treated with DMPP
to study its pharmacological effect on enteric viscerofugal neurons in the myenteric plexus of guinea-pig colon

生化/生理作用

1,1-Dimethyl-4-phenylpiperazinium iodide (DMPP) is a non-selective nicotinic acetylcholine receptor (nAchR) agonist. It acts as a stimulating agent for sympathetic ganglia. DMPP exhibits specific action on ganglia and adrenal medullary tissue hence, it finds its application in the diagnosis of pheochromocytoma.

特点和优势

This compound is featured on the Acetylcholine Receptors (Nicotinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.