D6571
3′,4′-二甲氧基黄酮
别名:
2-（3,4-二甲氧基苯基）苯并吡喃-4-酮, 3′,4′-DMF
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关于此项目
经验公式（希尔记法）:
C17H14O4
化学文摘社编号:
分子量:
282.29
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
assay
≥98% (HPLC)
Quality Level
form
powder
color
white to off-white
solubility
DMSO: ≥20 mg/mL
storage temp.
room temp
SMILES string
COc1ccc(cc1OC)C2=CC(=O)c3ccccc3O2
InChI
1S/C17H14O4/c1-19-15-8-7-11(9-17(15)20-2)16-10-13(18)12-5-3-4-6-14(12)21-16/h3-10H,1-2H3
InChI key
ZGHORMOOTZTQFL-UHFFFAOYSA-N
Application
3′,4′-二甲氧基黄酮已被用于脲酶抑制试验。
Biochem/physiol Actions
3′,4′-二甲氧基黄酮是一种黄酮化合物，其具有防止聚（ADP-核糖）（PAR）聚合物的产生和积累的能力。它可在皮质神经元中防御 N-甲基-D-天冬氨酸（NMDA）的毒性。3′,4′-二甲氧基黄酮是植物来源的多酚类黄酮类的成员。已知它具有抗氧化、抗癌、抗炎、抗动脉粥样硬化、降血脂和神经保护或神经营养作用。
3′,4′-二甲氧基黄酮是AhR的竞争性拮抗剂，其可抑制AhR介导的CYP1A1诱导，并且还在乳腺肿瘤细胞系中显示出抗雌激素活性。该化合物可阻断细胞溶质AhR复合物的转化，并形成核AhR复合物。
3′,4′-二甲氧基黄酮是芳香烃受体（AhR）的竞争性拮抗剂，其可抑制AhR介导的CYP1A1诱导，并且还在乳腺肿瘤细胞系中显示出抗雌激素活性。
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Identification through high-throughput screening of 4'-methoxyflavone and 3', 4'-dimethoxyflavone as novel neuroprotective inhibitors of parthanatos
Fatokun AA, et al.
British Journal of Pharmacology, 169(6), 1263-1278 (2013)
Flavonoids as natural inhibitors of jack bean urease Enzyme
AJ Awllia, et al.
Letters in Drug Design & Discovery, 13(3), 243-249 (2016)
Nada H Eisa et al.
International journal of molecular sciences, 21(21) (2020-10-30)
There is increasing evidence of the involvement of the tryptophan metabolite kynurenine (KYN) in disrupting osteogenesis and contributing to aging-related bone loss. Here, we show that KYN has an effect on bone resorption by increasing osteoclastogenesis. We have previously reported
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| D6571-5MG | 04061832824185 |
| D6571-25MG | 04061832824178 |