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Merck
CN

D6696

多拉克汀 合成的

别名:

多拉克汀, 25-环己基-5-O-去甲基-25-去(1-甲基丙基)阿维菌素

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关于此项目

经验公式(希尔记法):
C50H74O14
化学文摘社编号:
分子量:
899.11
NACRES:
NA.85
PubChem Substance ID:
UNSPSC Code:
51102829
MDL number:
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biological source

synthetic

assay

≥90%

form

solid

impurities

≤5% water (Karl Fischer)

color

white

solubility

methanol: soluble

antibiotic activity spectrum

parasites

mode of action

cell membrane | interferes

storage temp.

−20°C

SMILES string

[H][C@@]12OC/C3=C\C=C\[C@H](C)[C@H](O[C@@H]4C[C@H](OC)[C@@H](O[C@@H]5C[C@H](OC)[C@@H](O)[C@H](C)O5)[C@H](C)O4)\C(C)=C\CC6C[C@@H](C[C@]7(O6)O[C@@H]([C@@H](C)C=C7)C8CCCCC8)OC(=O)[C@H](C=C(C)[C@H]1O)[C@@]23O

InChI

1S/C50H74O14/c1-27-13-12-16-34-26-57-47-42(51)30(4)21-37(50(34,47)54)48(53)60-36-22-35(63-49(25-36)20-19-29(3)45(64-49)33-14-10-9-11-15-33)18-17-28(2)44(27)61-41-24-39(56-8)46(32(6)59-41)62-40-23-38(55-7)43(52)31(5)58-40/h12-13,16-17,19-21,27,29,31-33,35-47,51-52,54H,9-11,14-15,18,22-26H2,1-8H3/b13-12+,28-17+,34-16+/t27-,29-,31-,32-,35?,36-,37-,38-,39-,40+,41+,42+,43-,44-,45-,46-,47+,49+,50+/m0/s1

InChI key

QLFZZSKTJWDQOS-TTXKVKCHSA-N

Biochem/physiol Actions

Doramectin is a derivative of ivermectin. It is thought to work like other macrocyclic lactones by opening glutamate-gated chloride channels in the nerve cells, causing paralysis.

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Lact. - Repr. 2

存储类别

11 - Combustible Solids

wgk

WGK 3

法规信息

涉药品监管产品

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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D I Rendle et al.
The Veterinary record, 161(10), 335-338 (2007-09-11)
In equids, chorioptic mange is a common dermatitis for which there are no licensed medications in the uk. Doramectin and fipronil are licensed for the control of ectoparasites in other species and were evaluated for the treatment of 17 cases
C Cargill et al.
The Veterinary record, 138(19), 468-471 (1996-05-11)
Thirty-two pigs were infested experimentally with Sarcoptes scabiei var suis and allocated randomly to a medicated group (injected intramuscularly with 300 micrograms doramectin/kg) or an unmedicated group (injected intramuscularly with 1 ml saline/33 kg). They were observed daily for 15
Hamza Avcioglu et al.
Tropical animal health and production, 43(6), 1097-1099 (2011-02-26)
This study was conducted to investigate the efficacy of ivermectin (IVM), doramectin (DRM), and moxidectin (MXD) against Toxocara vitulorum in calves. In the study, 20 calves naturally infected with T. vitulorum were divided into four groups: three different treatment groups
Efficacy of weekly oral doramectin treatment in canine demodicosis.
N Murayama et al.
The Veterinary record, 167(2), 63-64 (2010-07-14)
Remo Lobetti
Veterinary journal (London, England : 1997), 193(1), 277-278 (2011-10-18)
The purpose of this study was to evaluate the effect of a daily oral dose of doramectin in dogs with spirocercosis. Twenty naturally infected dogs were treated with 0.5 mg/kg doramectin administered orally once daily for 42 days. In 13

全球贸易项目编号

货号GTIN
D6696-100MG04061833587843

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