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Merck
CN

D6696

Sigma-Aldrich

多拉克汀 合成的

别名:

多拉克汀, 25-环己基-5-O-去甲基-25-去(1-甲基丙基)阿维菌素

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关于此项目

经验公式（希尔记法）:
C50H74O14
化学文摘社编号:
117704-25-3
分子量:
899.11
MDL编号:
MFCD00894747
UNSPSC代码:
51102829
PubChem化学物质编号:
329798834
NACRES:
NA.85

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生物来源

synthetic

方案

≥90%

表单

solid

杂质

≤5% water (Karl Fischer)

颜色

white

溶解性

methanol: soluble

抗生素抗菌谱

parasites

作用机制

cell membrane | interferes

储存温度

−20°C

SMILES字符串

[H][C@@]12OC/C3=C\C=C\[C@H](C)[C@H](O[C@@H]4C[C@H](OC)[C@@H](O[C@@H]5C[C@H](OC)[C@@H](O)[C@H](C)O5)[C@H](C)O4)\C(C)=C\CC6C[C@@H](C[C@]7(O6)O[C@@H]([C@@H](C)C=C7)C8CCCCC8)OC(=O)[C@H](C=C(C)[C@H]1O)[C@@]23O

InChI

1S/C50H74O14/c1-27-13-12-16-34-26-57-47-42(51)30(4)21-37(50(34,47)54)48(53)60-36-22-35(63-49(25-36)20-19-29(3)45(64-49)33-14-10-9-11-15-33)18-17-28(2)44(27)61-41-24-39(56-8)46(32(6)59-41)62-40-23-38(55-7)43(52)31(5)58-40/h12-13,16-17,19-21,27,29,31-33,35-47,51-52,54H,9-11,14-15,18,22-26H2,1-8H3/b13-12+,28-17+,34-16+/t27-,29-,31-,32-,35?,36-,37-,38-,39-,40+,41+,42+,43-,44-,45-,46-,47+,49+,50+/m0/s1

InChI key

QLFZZSKTJWDQOS-TTXKVKCHSA-N

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生化/生理作用

Doramectin is a derivative of ivermectin. It is thought to work like other macrocyclic lactones by opening glutamate-gated chloride channels in the nerve cells, causing paralysis.

警示用语：

Warning

危险分类

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Lact. - Repr. 2

储存分类代码

11 - Combustible Solids

WGK

WGK 3

法规信息

涉药品监管产品
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
SLBJ5181V
041M1346V
041M1346

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D I Rendle et al.
The Veterinary record, 161(10), 335-338 (2007-09-11)
In equids, chorioptic mange is a common dermatitis for which there are no licensed medications in the uk. Doramectin and fipronil are licensed for the control of ectoparasites in other species and were evaluated for the treatment of 17 cases
Dürdane Kaya et al.
Veterinaria italiana, 46(1), 51-56 (2010-04-15)
The authors used 14 New Zealand rabbits (5 naturally infested rabbits and 9 in-contact rabbits) for Sarcoptes scabiei treatment in this study. Signs, such as itchy ears, eyes, tail and abdominal skin, alopecia and pyoderma, were considered to be the
Jian-Bo Wang et al.
Bioorganic & medicinal chemistry letters, 21(11), 3320-3323 (2011-04-26)
In an attempt to construct a strain that produces doramectin, the loading module of Ave polyketide synthase (PKS) from Streptomyces avermitilis M1 was replaced with a cyclohexanecarboxylic (CHC) unique loading module from phoslactomycin PKS. Additionally, the CHC-CoA biosynthetic gene cassette
R Pérez et al.
Veterinary parasitology, 170(1-2), 112-119 (2010-03-04)
A study was done to compare plasma disposition kinetics and the fecal elimination profile of doramectin (DRM) after oral or intramuscular (IM) administration in horses. Ten clinically healthy horses, 328-502 kg body weight (bw), were assigned to 2 experimental groups
María Del Mar Gil-Díaz et al.
Journal of agricultural and food chemistry, 59(19), 10635-10640 (2011-08-09)
Doramectin is a veterinary drug used as an antihelminthic and is excreted mainly in the feces as the nonmetabolized drug. This study investigated the time profile of doramectin excretion in pig feces and the potential transfer and persistence of doramectin
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