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Merck
CN

D6696

多拉克汀 合成的

别名:

多拉克汀, 25-环己基-5-O-去甲基-25-去(1-甲基丙基)阿维菌素

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关于此项目

经验公式（希尔记法）:
C50H74O14
化学文摘社编号:
117704-25-3
分子量:
899.11
NACRES:
NA.85
PubChem Substance ID:
329798834
UNSPSC Code:
51102829
MDL number:
MFCD00894747

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InChI key

QLFZZSKTJWDQOS-TTXKVKCHSA-N

SMILES string

[H][C@@]12OC/C3=C\C=C\[C@H](C)[C@H](O[C@@H]4C[C@H](OC)[C@@H](O[C@@H]5C[C@H](OC)[C@@H](O)[C@H](C)O5)[C@H](C)O4)\C(C)=C\CC6C[C@@H](C[C@]7(O6)O[C@@H]([C@@H](C)C=C7)C8CCCCC8)OC(=O)[C@H](C=C(C)[C@H]1O)[C@@]23O

InChI

1S/C50H74O14/c1-27-13-12-16-34-26-57-47-42(51)30(4)21-37(50(34,47)54)48(53)60-36-22-35(63-49(25-36)20-19-29(3)45(64-49)33-14-10-9-11-15-33)18-17-28(2)44(27)61-41-24-39(56-8)46(32(6)59-41)62-40-23-38(55-7)43(52)31(5)58-40/h12-13,16-17,19-21,27,29,31-33,35-47,51-52,54H,9-11,14-15,18,22-26H2,1-8H3/b13-12+,28-17+,34-16+/t27-,29-,31-,32-,35?,36-,37-,38-,39-,40+,41+,42+,43-,44-,45-,46-,47+,49+,50+/m0/s1

biological source

synthetic

assay

≥90%

form

solid

impurities

≤5% water (Karl Fischer)

color

white

solubility

methanol: soluble

antibiotic activity spectrum

parasites

mode of action

cell membrane | interferes

storage temp.

−20°C

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Biochem/physiol Actions

Doramectin is a derivative of ivermectin. It is thought to work like other macrocyclic lactones by opening glutamate-gated chloride channels in the nerve cells, causing paralysis.

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Lact. - Repr. 2

存储类别

11 - Combustible Solids

wgk

WGK 3

法规信息

涉药品监管产品
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分析证书(COA)

Lot/Batch Number
SLBJ5181V
041M1346V
041M1346

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D I Rendle et al.
The Veterinary record, 161(10), 335-338 (2007-09-11)
In equids, chorioptic mange is a common dermatitis for which there are no licensed medications in the uk. Doramectin and fipronil are licensed for the control of ectoparasites in other species and were evaluated for the treatment of 17 cases
C Cargill et al.
The Veterinary record, 138(19), 468-471 (1996-05-11)
Thirty-two pigs were infested experimentally with Sarcoptes scabiei var suis and allocated randomly to a medicated group (injected intramuscularly with 300 micrograms doramectin/kg) or an unmedicated group (injected intramuscularly with 1 ml saline/33 kg). They were observed daily for 15
Dürdane Kaya et al.
Veterinaria italiana, 46(1), 51-56 (2010-04-15)
The authors used 14 New Zealand rabbits (5 naturally infested rabbits and 9 in-contact rabbits) for Sarcoptes scabiei treatment in this study. Signs, such as itchy ears, eyes, tail and abdominal skin, alopecia and pyoderma, were considered to be the
María Del Mar Gil-Díaz et al.
Journal of agricultural and food chemistry, 59(19), 10635-10640 (2011-08-09)
Doramectin is a veterinary drug used as an antihelminthic and is excreted mainly in the feces as the nonmetabolized drug. This study investigated the time profile of doramectin excretion in pig feces and the potential transfer and persistence of doramectin
R Pérez et al.
Veterinary parasitology, 170(1-2), 112-119 (2010-03-04)
A study was done to compare plasma disposition kinetics and the fecal elimination profile of doramectin (DRM) after oral or intramuscular (IM) administration in horses. Ten clinically healthy horses, 328-502 kg body weight (bw), were assigned to 2 experimental groups
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