D7159
2′,3′-二脱氧胞苷 5′-三磷酸 钠盐
≥90% (HPLC)
别名:
ddCTP
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关于此项目
经验公式（希尔记法）:
C9H16N3O12P3
化学文摘社编号:
分子量:
451.16
UNSPSC Code:
12352202
PubChem Substance ID:
MDL number:
产品名称
2′,3′-二脱氧胞苷 5′-三磷酸 钠盐, ≥90% (HPLC)
InChI
1S/C9H16N3O12P3.Na/c10-7-3-4-12(9(13)11-7)8-2-1-6(22-8)5-21-26(17,18)24-27(19,20)23-25(14,15)16;/h3-4,6,8H,1-2,5H2,(H,17,18)(H,19,20)(H2,10,11,13)(H2,14,15,16);/q;+1/p-1/t6-,8+;/m0./s1
SMILES string
[Na+].NC1=NC(=O)N(C=C1)[C@H]2CC[C@@H](COP([O-])(=O)OP(O)(=O)OP(O)(O)=O)O2
InChI key
LOOMQRBEBYCFPP-QDOHZIMISA-M
biological source
synthetic (organic)
assay
≥90% (HPLC)
form
powder
solubility
water: 1 mg/mL, clear, colorless
storage temp.
−20°C
Application
通过X射线晶体学研究了ddCTP与DNA聚合酶β的复合物，对HIV逆转录酶的抑制活性有影响。
Biochem/physiol Actions
DNA 聚合酶 I 催化的链延伸抑制剂。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Journal of natural products, 68(7), 979-984 (2005-07-26)
Five new acylphloroglucinol derivatives, mahureones A-E (1, 3-6), have been isolated from the leaves of Mahurea palustris, and their structures determined by spectroscopic means. During the isolation process, several byproducts (7-9) were formed by reaction of one of the isoprenyl
Yaligara Veeranagouda et al.
BMC genomics, 15, 429-429 (2014-06-06)
Bacteroides fragilis is a Gram-negative anaerobe that is normally a human gut commensal; it comprises a small percentage of the gut Bacteroides but is the most frequently isolated Bacteroides from human infections. Identification of the essential genes necessary for the
Michal R Szymanski et al.
The EMBO journal, 34(14), 1959-1970 (2015-06-10)
The human DNA polymerase gamma (Pol γ) is responsible for DNA replication in mitochondria. Pol γ is particularly susceptible to inhibition by dideoxynucleoside-based inhibitors designed to fight viral infection. Here, we report crystal structures of the replicating Pol γ-DNA complex
Nutjaree Jeenduang et al.
Clinica chimica acta; international journal of clinical chemistry, 442, 36-43 (2015-01-17)
Cardiovascular disease (CVD) is one of the major causes of death worldwide. Numerous genetic risk factors in lipid metabolism, including mutations of LDLR, APOB, and PCSK9, as well as polymorphisms of CETP and APOE, have been found to associate with
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