D7400
2′-脱氧腺苷 一水合物
≥99%, synthetic (organic), powder
别名:
9-（2-脱氧-β- D -呋喃核糖基）腺嘌呤, 腺嘌呤脱氧核苷
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关于此项目
经验公式（希尔记法）:
C10H13N5O3 · H2O
化学文摘社编号:
分子量:
269.26
Beilstein:
91015
EC 号:
MDL编号:
UNSPSC代码:
41106305
PubChem化学物质编号:
NACRES:
NA.51
产品名称
2′-脱氧腺苷 一水合物, ≥99%
生物来源
synthetic (organic)
方案
≥99%
表单
powder
溶解性
water: 25 mg/mL, clear to slightly hazy, colorless to faintly yellow
储存温度
2-8°C
SMILES字符串
[H]O[H].Nc1ncnc2n(cnc12)[C@H]3C[C@H](O)[C@@H](CO)O3
InChI
1S/C10H13N5O3/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(17)6(2-16)18-7/h3-7,16-17H,1-2H2,(H2,11,12,13)/t5-,6+,7+/m0/s1
InChI key
OLXZPDWKRNYJJZ-RRKCRQDMSA-N
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应用
2′-脱氧腺苷一水合物用于：
- 作为核苷补充品成分
- 作为标准品，估算增殖油棕胚性悬浮液中的DNA总甲基化率
- 逆转无菌α基序（SAM）和含组氨酸-天冬氨酸（HD）结构域的蛋白（SAMHD1）
- 抑制人类免疫缺陷病毒（HIV-1）和乙型肝炎病毒（HBV）
生化/生理作用
2′-脱氧腺苷（2′-dAdo），是脱氧核糖核苷，在能量应激的情况下可能被某些细胞用作能源，影响 cAMP的水平。 2′-dAdo 用于腺苷类似物在各种生物过程中功能的比较研究。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
M Nakamura et al.
The Journal of biological chemistry, 257(23), 13945-13950 (1982-12-10)
Regulation of glucose metabolism in glycolysis by round spermatids was studied. Assay of activities of 11 glycolytic enzymes in cell-free spermatid extracts showed that hexokinase, phosphofructokinase, and glyceraldehyde-3-phosphate dehydrogenase had the lowest activities. When the cells were incubated with glucose
O Magnus et al.
International journal of fertility, 38(2), 123-128 (1993-03-01)
To find differences in effect on sperm motility of agents that increase intracellular cAMP: manganese ion, methyl-isobutyl-xanthine (MIX), 2-deoxyadenosine, glucose, and Mn-MIX and Mn-glucose. Nine men with asthenozoospermia vs. fertile donors. Sperm was washed in Hepes-buffered saline, motility tested by
Don E Farthing et al.
Scientific reports, 7(1), 4043-4043 (2017-06-24)
Deuterated water (
SAMHD1 Modulates Early Steps during Human Cytomegalovirus Infection by Limiting NF-kappaB Activation
Kim ET, et al.
Testing, 28(2), 434-448 (2019)
Michela Giannecchini et al.
The international journal of biochemistry & cell biology, 37(4), 797-808 (2005-02-08)
In this paper, we report that cells undergoing metabolic stress conditions may use the ribose moiety of nucleosides as energy source to slow down cellular damage. In fact, the phosphorolytic cleavage of the N-glycosidic bond of nucleosides generates, without energy
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