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D7692

磷酸二乙基伞形酮

Name: 磷酸二乙基伞形酮
Brand: SIGMA

≥98% (HPLC), cholesterol esterase inhibitor, oil

别名:

DEUP, UBP

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关于此项目

经验公式（希尔记法）:

C₁₄H₁₇O₆P

化学文摘社编号:

897-83-6

分子量:

312.25

UNSPSC Code:

12352200

PubChem Substance ID:

24894155

NACRES:

NA.77

Assay:

≥98% (HPLC)

Form:

oil

Quality level:

100

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属性

产品名称

磷酸二乙基伞形酮, ≥98% (HPLC), oil

Quality Level

100

assay

≥98% (HPLC)

form

oil

color

colorless to yellow

solubility

DMSO: >5 mg/mL

storage temp.

−20°C

SMILES string

CCOP(=O)(OCC)Oc1ccc2C(C)=CC(=O)Oc2c1

InChI

1S/C14H17O6P/c1-4-17-21(16,18-5-2)20-11-6-7-12-10(3)8-14(15)19-13(12)9-11/h6-9H,4-5H2,1-3H3

InChI key

GHGRYKAFUNNHBG-UHFFFAOYSA-N

说明

Application

磷酸二乙酯已被用作脂肪酶抑制剂来治疗野生型成髓细胞，以进行体外中性粒细胞分化试验。

Biochem/physiol Actions

二乙基伞形酮磷酸酯是一种选择性的、有效的胆固醇酯酶抑制剂。它主要通过防止胆固醇转运到类固醇生成细胞的线粒体中来阻止类固醇生成。预期胆固醇酯酶抑制剂会限制饮食中胆固醇的吸收。IC₅₀ = 11.6 μM。

二乙基伞形磷酸酯（DEUP）是一种在体外不阻断蛋白激酶活性A的有机磷酸酯。

pictograms

GHS06

signalword

Danger

hcodes

H300

pcodes

P264 - P270 - P301 + P310 - P405 - P501

Hazard Classifications

Acute Tox. 2 Oral

存储类别

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

历史批次信息供参考:

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Lot/Batch Number

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商品

Cholesterol Esterification

Cholesterol esterification enhances transport efficiency in lipoproteins for increased blood stream transport.

胆固醇酯化TEST

胆固醇酯化可改善运输。胆固醇酯可更轻松地封装在脂蛋白内部-增加了在血液中可轻松运输的胆固醇数量。

Stability of vertical posture explored with unexpected mechanical perturbations: synergy indices and motor equivalence.

Momoko Yamagata et al.

Experimental brain research, 236(5), 1501-1517 (2018-03-23)

We explored the relations between indices of mechanical stability of vertical posture and synergy indices under unexpected perturbations. The main hypotheses predicted higher posture-stabilizing synergy indices and higher mechanical indices of center of pressure stability during perturbations perceived by subjects

High-capacity selective uptake of cholesteryl ester from native LDL during macrophage foam cell formation.

Jason M Meyer et al.

Journal of lipid research, 53(10), 2081-2091 (2012-07-27)

Macrophage foam cells are a defining pathologic feature of atherosclerotic lesions. Recent studies have demonstrated that at high concentrations associated with hypercholesterolemia, native LDL induces macrophage lipid accumulation. LDL particles are taken up by macrophages as part of bulk fluid

Evidence that a neutral cholesteryl ester hydrolase is responsible for the extralysosomal hydrolysis of high-density lipoprotein cholesteryl ester in rat hepatoma cells (Fu5AH).

J G Delamatre et al.

Journal of cellular physiology, 157(1), 164-168 (1993-10-01)

Diethylumbelliferyl phosphate (UBP) has been shown to inhibit the neutral cholesteryl ester hydrolase activity responsible for hydrolysis of cellular lipid droplet cholesteryl ester (Harrison et al., 1990). The potential for (UBP) to inhibit uptake and hydrolysis of high density lipoprotein

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全球贸易项目编号

货号	GTIN
D7692-5MG	04061833588758
D7692-25MG	04061833057506