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E0514

E-64c

Name: E-64c
Brand: SIGMA

Calpain Inhibitor

别名:

(2S,3S)-trans-Epoxysuccinyl-L-leucylamido-3-methylbutane

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关于此项目

经验公式（希尔记法）:

C₁₅H₂₆N₂O₅

化学文摘社编号:

76684-89-4

分子量:

314.38

UNSPSC Code:

12352202

PubChem Substance ID:

24894369

MDL number:

MFCD00132882

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属性

biological source

synthetic (organic)

assay

≥98% (HPLC)

form

powder

solubility

ethanol: 20 mg/mL, clear, colorless

storage temp.

−20°C

SMILES string

CC(C)CCNC(=O)[C@H](CC(C)C)NC(=O)[C@H]1O[C@@H]1C(O)=O

InChI

1S/C15H26N2O5/c1-8(2)5-6-16-13(18)10(7-9(3)4)17-14(19)11-12(22-11)15(20)21/h8-12H,5-7H2,1-4H3,(H,16,18)(H,17,19)(H,20,21)/t10-,11-,12-/m0/s1

InChI key

SCMSYZJDIQPSDI-SRVKXCTJSA-N

Gene Information

human ... CAPN1(823)

说明

Biochem/physiol Actions

Cysteine protease inhibitor; membrane-impermeable calpain inhibitor.

Cysteine protease inhibitor; membrane-impermeable calpain inhibitor. Significantly reduces calpain-mediated depletion of microtubule-associated protein (MAP2) in an animal model of an ischemic brain.

Other Notes

Synthetic analog of E-64

存储类别

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

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Autophagy in tobacco BY-2 cells cultured under sucrose starvation conditions: isolation of the autolysosome and its characterization.

Chihiro Takatsuka et al.

Plant & cell physiology, 52(12), 2074-2087 (2011-11-01)

Tobacco culture cells carry out a large-scale degradation of intracellular proteins in order to survive under sucrose starvation conditions. We have previously suggested that this bulk degradation of cellular proteins is performed by autophagy, where autolysosomes formed de novo act

Michael acceptors as cysteine protease inhibitors.

Maria M M Santos et al.

Mini reviews in medicinal chemistry, 7(10), 1040-1050 (2007-11-06)

Cysteine proteases selectively catalyze the hydrolysis of peptide bonds. Uncontrolled, unregulated, or undesired proteolysis can lead to many disease states including emphysema, stroke, viral infections, cancer, Alzheimer's disease, inflammation, and arthritis. Cysteine proteases inhibitors thus have considerable potential utility for

A calcium stimulated cysteine protease involved in isoproterenol induced cardiac hypertrophy.

G D Arthur et al.

Molecular and cellular biochemistry, 176(1-2), 241-248 (1997-12-24)

The purpose of this study was to test the relationship between biochemical and functional changes accompanying beta-agonist induced cardiac hypertrophy and the activation of a calcium stimulated cysteine protease. Because the ultrastructural and ionic changes accompanying beta-agonist induced cardiac hypertrophy

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全球贸易项目编号

货号	GTIN
E0514-5MG	04061833270646