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E0761

Ebelactone A microbial

Name: Ebelactone A microbial
Brand: SIGMA

esterase inhibitor

别名:

3,11-Dihydroxy-2,4,6,8,10,12-hexamethyl-9-oxo-6-tetradecenoic acid 1,3-lactone

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关于此项目

经验公式（希尔记法）:

C₂₀H₃₄O₄

化学文摘社编号:

76808-16-7

分子量:

338.48

NACRES:

NA.77

PubChem Substance ID:

24894373

UNSPSC Code:

12352202

MDL number:

MFCD00036710

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biological source

Streptomyces sp.

Quality Level

100

assay

≥98% (HPLC)

form

powder

solubility

methanol: 10 mg/mL, clear, colorless

storage temp.

2-8°C

SMILES string

[H][C@@]1([C@H](C/C(C)=C/[C@H](C([C@H]([C@@H]([C@@H](CC)C)O)C)=O)C)C)OC([C@H]1C)=O

InChI

1S/C20H34O4/c1-8-12(3)17(21)15(6)18(22)13(4)9-11(2)10-14(5)19-16(7)20(23)24-19/h9,12-17,19,21H,8,10H2,1-7H3/b11-9+/t12-,13-,14+,15+,16+,17-,19+/m1/s1

InChI key

WOISDAHQBUYEAF-QIQXJRRPSA-N

General description

Esterase inhibitors produced by Streptomyces sp. MG7-G1 strain

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

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β-Lactone natural products and derivatives inactivate homoserine transacetylase, a target for antimicrobial agents.

Gianfranco De Pascale et al.

The Journal of antibiotics, 64(7), 483-487 (2011-04-28)

Homoserine transacetylase (HTA) catalyzes the transfer of an acetyl group from acetyl-CoA to the hydroxyl group of homoserine. This is the first committed step in the biosynthesis of methionine (Met) from aspartic acid in many fungi, Gram-positive and some Gram-negative

In vitro inhibition of esterase activity in amniotic fluid: comparison with bacterial cultures.

I A Hoskins et al.

American journal of obstetrics and gynecology, 163(6 Pt 1), 1944-1947 (1990-12-01)

Assessment of leukocyte esterase activity in amniotic fluid for the rapid and reliable diagnosis of chorioamnionitis has been demonstrated previously. We compared in vitro inhibition of esterase activity in amniotic fluid with bacterial cultures to identify the origins of the

Low-molecular-weight immunomodifiers produced by micro-organisms.

H Umezawa

Biotechnology & genetic engineering reviews, 3, 255-273 (1985-01-01)

Human acylpeptide hydrolase. Studies on its thiol groups and mechanism of action.

A Scaloni et al.

The Journal of biological chemistry, 269(21), 15076-15084 (1994-05-27)

The presence of a cysteine residue(s) near the active site of acylpeptide hydrolase was suggested by inactivation of the enzyme with sulfhydryl-modifying agents and by the substantial protection against inactivation afforded by the competitive inhibitor acetylmethionine. 5,5'-dithiobis-(2-nitrobenzoate) titrations of the

Stereocontrolled total synthesis of (-)-ebelactone A.

Amit K Mandal

Organic letters, 4(12), 2043-2045 (2002-06-07)

[structure: see text] The highly stereocontrolled hydroboration of an alkene, a subsequent Suzuki-Miyaura cross-coupling reaction, a silylcupration on a nonterminal acetylene, and an iododesilylation were the key steps in a convergent total synthesis of (-)-ebelactone A.

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全球贸易项目编号

货号	GTIN
E0761-1MG	04061833601228

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