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Merck
CN

E1378

七叶皂苷

≥95%, powder

别名:

七叶皂甙

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关于此项目

化学文摘社编号:
6805-41-0
NACRES:
NA.25
PubChem Substance ID:
24894403
UNSPSC Code:
12352201
EC Number:
229-880-6
MDL number:
MFCD00076054

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产品名称

七叶皂苷, ≥95%, powder

Quality Level

200

InChI key

AXNVHPCVMSNXNP-YSYFQUGBSA-N

InChI

1S/C55H86O24/c1-10-23(2)46(71)79-43-44(72-24(3)60)55(22-59)26(17-50(43,4)5)25-11-12-30-51(6)15-14-32(52(7,21-58)29(51)13-16-53(30,8)54(25,9)18-31(55)61)75-49-41(77-48-38(67)36(65)34(63)28(20-57)74-48)39(68)40(42(78-49)45(69)70)76-47-37(66)35(64)33(62)27(19-56)73-47/h10-11,26-44,47-49,56-59,61-68H,12-22H2,1-9H3,(H,69,70)/b23-10+/t26?,27-,28-,29?,30?,31-,32?,33-,34-,35+,36+,37-,38-,39+,40+,41-,42+,43?,44+,47+,48-,49-,51?,52-,53?,54-,55?/m1/s1

SMILES string

C\C=C(/C)C(=O)OC1[C@H](OC(C)=O)C2(CO)[C@H](O)C[C@]3(C)C(=CCC4C5(C)CCC(O[C@@H]6O[C@@H]([C@@H](O[C@@H]7O[C@H](CO)[C@@H](O)[C@H](O)[C@H]7O)[C@H](O)[C@H]6O[C@H]8O[C@H](CO)[C@@H](O)[C@H](O)[C@H]8O)C(O)=O)[C@](C)(CO)C5CCC34C)C2CC1(C)C

biological source

plant (Aesculus chinensis)

assay

≥95%

form

powder

impurities

≤6.0% Water (Karl Fischer)

color

white

solubility

methanol: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow

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相关类别

Application

七叶皂苷是从七叶树（ 七叶树 ）种子中分离得到的三萜皂苷的天然混合物，被用作血管保护性抗炎、抗水肿和抗疼痛药物并进行研究。可用于研究其作为 NF-κ 的化疗增敏剂和调节剂的药代动力学、安全性和有效性B 细胞信号传导。

Other Notes

为了全面了解我们针对客户研究提供的各种多糖产品，建议您访问我们的碳水化合物分类页面。

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Inhalation - Acute Tox. 4 Oral

存储类别

11 - Combustible Solids

wgk

WGK 2

ppe

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
BCCN2305
BCCK4522
BCCJ1445
BCCF5567
BCCC9208

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Wenyu Xin et al.
Phytomedicine : international journal of phytotherapy and phytopharmacology, 18(4), 272-277 (2010-09-21)
Escin, a natural mixture of triterpenoid saponins isolated from the seed of the horse chestnut (Aesculus hippocastanum), had been demonstrated to possess anti-edematous and anti-inflammatory effects. The present study was designed to investigate whether escin exhibits synergistic anti-inflammatory effects when
Kuzhuvelil B Harikumar et al.
Molecular pharmacology, 77(5), 818-827 (2010-01-28)
Agents that can enhance tumor cell apoptosis and inhibit invasion have potential for the treatment of cancer. Here, we report the identification of escin, a pentacyclic triterpenoid from horse chestnut that exhibits antitumor potential against leukemia and multiple myeloma. Whether
Hang Zhao et al.
Canadian journal of anaesthesia = Journal canadien d'anesthesie, 54(3), 201-207 (2007-03-03)
The purpose of this study was to determine if intrathecal landiolol, a beta1-blocker, can modulate formalin-induced nociception and spinal c-Fos expression in mice, in the absence of anesthesia. Thirty-two mice were randomly assigned to one of four groups: the control
Ellen De Geyter et al.
Pest management science, 68(2), 164-169 (2011-07-01)
Saponins are a class of secondary plant metabolites consisting of a sugar moiety glycosidically linked to a hydrophobic aglycone (sapogenin) that often possess insecticidal activities. Four saponins were selected: two triterpene saponins, Q. saponaria saponins and aescin, and two steroidal
Hye Young Kim et al.
Naunyn-Schmiedeberg's archives of pharmacology, 385(2), 191-202 (2011-10-14)
3',4'-Dihydroxyflavonol (DiOHF) exerts endothelium-independent relaxation in rat aortic rings. In this study, we hypothesized that DiOHF reduces vascular contraction through Ca²⁺ desensitization in permeabilized third-order branches of rat mesenteric arteries. The third-order branches of rat mesenteric arteries were permeabilized with
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