E1636
β-Estradiol 3,17-disulfate dipotassium salt
≥95%
别名:
1,3,5(10)-Estratriene 3,17β-disulfate, 3,17β-Dihydroxy-1,3,5(10)-estratriene disulfate
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关于此项目
线性分子式:
C18H22O8S2K2
化学文摘社编号:
分子量:
508.69
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
51111800
MDL number:
Biological source:
synthetic
Form:
powder
Assay:
≥95%
InChI
1S/C18H24O8S2.K.H/c1-18-9-8-14-13-5-3-12(25-27(19,20)21)10-11(13)2-4-15(14)16(18)6-7-17(18)26-28(22,23)24;;/h3,5,10,14-17H,2,4,6-9H2,1H3,(H,19,20,21)(H,22,23,24);;/t14-,15-,16+,17+,18+;;/m1../s1
SMILES string
[K].[H][C@]12CC[C@]3(C)[C@H](CC[C@@]3([H])[C@]1([H])CCc4cc(OS(O)(=O)=O)ccc24)OS(O)(=O)=O
InChI key
CPIZVUIARARPNO-LBARCDFESA-N
biological source
synthetic
assay
≥95%
form
powder
technique(s)
inhibition assay: suitable
solubility
water: 50 mg/mL, clear, colorless
shipped in
ambient
storage temp.
−20°C
Biochem/physiol Actions
Among other effects, this conjugated estrogen selectively inhibits glutathione S-transferases.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
涉药品监管产品
此项目有
J J Barycki et al.
Archives of biochemistry and biophysics, 345(1), 16-31 (1997-09-01)
3beta-(Iodoacetoxy)dehydroisoandrosterone (3beta-IDA), an analogue of the electrophilic substrate, Delta5-androstene-3,17-dione, as well as an analogue of several other steroid inhibitors of glutathione S-transferase, was tested as an affinity label of rat liver glutathione S-transferase, isozyme 1-1. A time-dependent loss of enzyme
J D Bain et al.
Steroids, 43(6), 603-619 (1984-06-01)
The efficiencies for estrogen conjugate hydrolysis were compared between enzyme hydrolysis, acid solvolysis and a new method, ammonolysis. Samples included: 1) crystalline 1,3,5(10)-estratriene-3, 17 beta-diol disulfate (estradiol 3,17-disulfate), 2) squirrel monkey urine collected following an intravenous injection of [2,4,6,7-H] 1,3,5(10)-estratriene-3,17
Angelo Quaranta et al.
PloS one, 4(11), e7699-e7699 (2009-11-06)
Dramatic declines in amphibian populations have been described all over the world since the 1980s. The evidence that the sensitivity to environmental threats is greater in amphibians than in mammals has been generally linked to the observation that amphibians are
Selective inhibition of glutathione S-transferases by 17 beta-estradiol disulfate.
V S Ohl et al.
Archives of biochemistry and biophysics, 180(1), 186-190 (1977-04-15)
P Angerer et al.
Journal of the American College of Cardiology, 36(6), 1789-1796 (2000-11-25)
The study objective was to clarify in a randomized, controlled, observer-blind trial whether hormone replacement therapy (HRT) improves elastic properties of the common carotid artery in women with signs of subclinical atherosclerosis, especially in subgroups with increased risk, and whether
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