E3380
椭圆玫瑰树碱
synthetic
别名:
5,11-二甲基-6H-吡啶并[4,3-b]咔唑
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关于此项目
经验公式（希尔记法）:
C17H14N2
化学文摘社编号:
分子量:
246.31
EC Number:
208-264-0
UNSPSC Code:
12352200
PubChem Substance ID:
Beilstein/REAXYS Number:
221300
MDL number:
InChI key
CTSPAMFJBXKSOY-UHFFFAOYSA-N
InChI
1S/C17H14N2/c1-10-14-9-18-8-7-12(14)11(2)17-16(10)13-5-3-4-6-15(13)19-17/h3-9,19H,1-2H3
SMILES string
Cc1c2ccncc2c(C)c3c4ccccc4[nH]c13
biological source
synthetic
storage temp.
2-8°C
Gene Information
human ... CYP1A1(1543), CYP1A2(1544), KIT(3815), TOP2A(7153)
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Biochem/physiol Actions
Ellipticine is an antitumor alkaloid isolated from Ochrosia sp. It inhibits cytochrome P450 (CYP1A1) and DNA topoisomerase II activities.
signalword
Danger
hcodes
pcodes
Hazard Classifications
Acute Tox. 3 Oral
存储类别
6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
法规信息
新产品
此项目有
Uraiwan Songsiang et al.
Journal of natural products, 74(2), 208-212 (2011-02-10)
Four new carbazole alkaloids, claurailas A-D (1-4), as well as 12 known carbazoles and three known coumarins were isolated from the roots of Clausena harmandiana. Heptaphylline (6) and 7-methoxyheptaphylline (7) showed strong cytotoxicity against NCI-H187 and KB cell lines with
Sheng Lu et al.
Journal of controlled release : official journal of the Controlled Release Society, 160(1), 33-40 (2012-04-03)
The current drug delivery techniques involve encapsulation, targeting and controlled release of the drug with various molecules or nanoparticles, but rarely has the drug molecular state or form been investigated. It is necessary to deliver a drug with a prescribed
Jonathan Sperry et al.
Bioorganic & medicinal chemistry, 17(20), 7131-7137 (2009-09-29)
A series of pyranonaphthoquinone derivatives related to the known topoisomerase II inhibitor eleutherin 1 have been shown to act as specific topoisomerase II catalytic inhibitors, with several analogues displaying greater potency than the natural product itself. Amongst the compounds tested
Manel Romero et al.
Journal of medicinal chemistry, 50(2), 294-307 (2007-01-19)
A set of disubstituted tetracyclic lactones has been synthesized and tested for potential antitumor activity. Several of them possess a noticeable cytotoxicity against L1210 and HT-29 colon cells in vitro. Relationships between chain nature and biological properties were sought. Lactones
Robert A DiStasio et al.
Proceedings of the National Academy of Sciences of the United States of America, 109(37), 14791-14795 (2012-08-28)
Van der Waals (vdW) interactions are ubiquitous in molecules and condensed matter, and play a crucial role in determining the structure, stability, and function for a wide variety of systems. The accurate prediction of these interactions from first principles is
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