E3380
椭圆玫瑰树碱
synthetic
别名:
5,11-二甲基-6H-吡啶并[4,3-b]咔唑
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经验公式（希尔记法）:
C17H14N2
化学文摘社编号:
分子量:
246.31
EC Number:
208-264-0
UNSPSC Code:
12352200
PubChem Substance ID:
Beilstein/REAXYS Number:
221300
MDL number:
InChI key
CTSPAMFJBXKSOY-UHFFFAOYSA-N
InChI
1S/C17H14N2/c1-10-14-9-18-8-7-12(14)11(2)17-16(10)13-5-3-4-6-15(13)19-17/h3-9,19H,1-2H3
SMILES string
Cc1c2ccncc2c(C)c3c4ccccc4[nH]c13
biological source
synthetic
storage temp.
2-8°C
Gene Information
human ... CYP1A1(1543), CYP1A2(1544), KIT(3815), TOP2A(7153)
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Biochem/physiol Actions
Ellipticine is an antitumor alkaloid isolated from Ochrosia sp. It inhibits cytochrome P450 (CYP1A1) and DNA topoisomerase II activities.
signalword
Danger
hcodes
pcodes
Hazard Classifications
Acute Tox. 3 Oral
存储类别
6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
法规信息
新产品
此项目有
Roli Bawa et al.
Nanomedicine : nanotechnology, biology, and medicine, 8(5), 647-654 (2011-09-06)
A special class of self-assembling peptide (EAK16-II) has been found to stabilize the hydrophobic anticancer agent ellipticine (EPT) in aqueous solution. In this study, the mechanism of such peptide-EPT complexes to enhance cellular delivery and anticancer activity was evaluated. Results
Věra Kotrbová et al.
Biochemical pharmacology, 82(6), 669-680 (2011-06-21)
Ellipticine is a pro-drug, whose activation is dependent on its oxidation by cytochromes P450 (CYP) and peroxidases. Cytochrome b(5) alters the ratio of ellipticine metabolites formed by isolated reconstituted CYP1A1 and 1A2, favoring formation of 12-hydroxy- and 13-hydroxyellipticine metabolites implicated
Yan Wu et al.
International journal of nanomedicine, 7, 3221-3233 (2012-07-18)
Applications of the anticancer agent, ellipticine, have been limited by its hydrophobicity and toxicity. An efficient delivery system is required to exploit the enormous potential of this compound. Recently, EAK16-II, an ionic-complementary, self-assembling peptide, has been found to stabilize ellipticine
Rocío Argotte-Ramos et al.
Journal of natural products, 69(10), 1442-1444 (2006-10-28)
The EtOAc extract of the stem bark of Hintonia latiflora showed the suppression of total parasitemia and the chemosuppression of schizont numbers, when tested in vivo against Plasmodium berghei infection in mice. Bioassay-directed fractionation of the EtOAc extract, using the
Jonathan Sperry et al.
Bioorganic & medicinal chemistry, 17(20), 7131-7137 (2009-09-29)
A series of pyranonaphthoquinone derivatives related to the known topoisomerase II inhibitor eleutherin 1 have been shown to act as specific topoisomerase II catalytic inhibitors, with several analogues displaying greater potency than the natural product itself. Amongst the compounds tested
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