E4392
棘霉素
90-95%
别名:
Quinomycin A
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关于此项目
经验公式（希尔记法）:
C51H64N12O12S2
化学文摘社编号:
分子量:
1101.26
PubChem Substance ID:
UNSPSC Code:
51101500
MDL number:
Beilstein/REAXYS Number:
78671
SMILES string
CS[C@H]1SC[C@@H]2N(C)C(=O)[C@H](C)NC(=O)[C@@H](COC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]1N(C)C(=O)[C@H](C)NC(=O)[C@@H](COC(=O)[C@H](C(C)C)N(C)C2=O)NC(=O)c3cnc4ccccc4n3)NC(=O)c5cnc6ccccc6n5
assay
90-95%
mode of action
DNA synthesis | interferes
storage temp.
2-8°C
General description
Chemical structure: peptide
Biochem/physiol Actions
Powerful antimicrobial and antitumor agent; selectively inhibits nucleic acid synthesis in vitro. Binds to DNA by a bifunctional mode of intercalation.
Other Notes
A cyclodepsipeptide antibiotic with quinoxaline functionality
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Repr. 2
存储类别
6.1B - Non-combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
法规信息
新产品
此项目有
Echinomycin: a bifunctional intercalating antibiotic.
M J Waring et al.
Nature, 252(5485), 653-657 (1974-12-20)
K R Fox et al.
Nucleic acids research, 18(8), 1957-1963 (1990-04-25)
DNA fragments containing the sequence CG(AT)nCG have been used in footprinting experiments to assess the effect of echinomycin, which binds to CG steps, on the structure of the central AT region. DNAase I normally cuts ApT much better than TpA;
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