E4632
益康唑 硝酸盐
别名:
1-(2-[(4-Chlorophenyl)methoxy]-2-[2,4-dichlorophenyl]ethyl)-1H-imidazole
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关于此项目
经验公式（希尔记法）:
C18H15Cl3N2O · HNO3
化学文摘社编号:
分子量:
444.70
NACRES:
NA.85
PubChem Substance ID:
UNSPSC Code:
51102829
EC Number:
246-053-5
MDL number:
InChI key
DDXORDQKGIZAME-UHFFFAOYSA-N
InChI
1S/C18H15Cl3N2O.HNO3/c19-14-3-1-13(2-4-14)11-24-18(10-23-8-7-22-12-23)16-6-5-15(20)9-17(16)21;2-1(3)4/h1-9,12,18H,10-11H2;(H,2,3,4)
SMILES string
O[N+]([O-])=O.Clc1ccc(COC(Cn2ccnc2)c3ccc(Cl)cc3Cl)cc1
form
powder or crystals
color
white to off-white
antibiotic activity spectrum
Gram-positive bacteria
fungi
mode of action
cell membrane | interferes
cell wall synthesis | interferes
enzyme | inhibits
Quality Level
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Application
Econazole is a broad spectrum antimycotic similar to ketoconazole. It has some action against Gram positive bacteria. It is used topically in dermatomycoses as well as orally and parenterally. It is used for studies on processes such as platelet serotonin uptake, prostanoid biosynthesis, EDHF-mediated relaxation, and Ca2+ transport pathways in thymic lymphocytes.
Biochem/physiol Actions
Econazole interacts with 14-α demethylase, a cytochrome P-450 enzyme necessary to convert lanosterol to ergosterol. Inhibition of ergosterol results in increased cellular permeability causing leakage of cellular contents. Econazole may also inhibit endogenous respiration, interact with membrane phospholipids, inhibit the transformation of yeasts to mycelial forms, inhibit purine uptake, and impair triglyceride and phospholipid biosynthesis.
General description
Chemical structure: imidazole
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
C J Jackson et al.
FEMS microbiology letters, 192(2), 159-162 (2000-11-07)
Azole antifungals are central to therapy and act by inhibiting a cytochrome P450, sterol 14-demethylase and blocking normal sterol synthesis. Our recent identification of a mycobacterial sterol biosynthetic pathway led us to probe the efficacy of a range of these
Inhibition of Ca2+ transport pathways in thymic lymphocytes by econazole, miconazole, and SKF 96365
M. J. Mason, B. Mayer, et al.
American Journal of Physiology. Cell Physiology, 264, C654-C662 (1993)
M A Ghannoum et al.
Clinical microbiology reviews, 12(4), 501-517 (1999-10-09)
The increased use of antibacterial and antifungal agents in recent years has resulted in the development of resistance to these drugs. The significant clinical implication of resistance has led to heightened interest in the study of antimicrobial resistance from different
Alessandro Malara et al.
The Journal of biological chemistry, 292(8), 3239-3251 (2017-01-05)
Abscisic acid (ABA) is a phytohormone involved in pivotal physiological functions in higher plants. Recently, ABA has been proven to be also secreted and active in mammals, where it stimulates the activity of innate immune cells, mesenchymal and hematopoietic stem
Núria Daranas et al.
Applied and environmental microbiology, 84(10) (2018-03-11)
A viability quantitative PCR (v-qPCR) assay was developed for the unambiguous detection and quantification of Lactobacillus plantarum PM411 viable cells in aerial plant surfaces. A 972-bp region of a PM411 predicted prophage with mosaic architecture enabled the identification of a
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