E5627
Erythropoietin 人
recombinant, expressed in CHO cells, lyophilized powder, suitable for cell culture, ~100,000 units/mg protein
别名:
EPO
生物来源
human
质量水平
重组
expressed in CHO cells
表单
lyophilized powder
比活
~100,000 units/mg protein
包装
pkg of 10UN
技术
cell culture | mammalian: suitable
颜色
white
UniProt登记号
储存温度
−20°C
基因信息
human ... EPO(2056), EPOR(2057)
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一般描述
Erythropoietin is a glycoprotein cytokine and hormone and belongs to the type I cytokine superfamily. It undergoes posttranslational modifications and exists as 18 and 30 kDa molecular weight forms. It is mapped to human chromosome 7q22.
应用
Erythropoietin human has been used:
- as a component of cardiac stem cell medium
- to test its neuroprotective effect on diabetic mice
- to test its effect on hippocampal synapses in mice
生化/生理作用
Erythropoietin is a glycoprotein that is the principal regulator of red blood cell growth and differentiation.
Erythropoietin (EPO) elicits antiapoptotic, anti-inflammatory and tissue protective functions. EPO is essential for maintaining red blood progenitor cells. It is used for treating hematological disorders and in perioperative therapies. A homozygous mutation in EPO gene obstructs its interaction with receptor and the signaling cascade resulting in severe anemia. Elevated levels of EPO due to mutations is implicated in the pathogenesis of familial erythrocytosis.
外形
Lyophilized as 10 units EPO, 10 mg trisodium citrate and 10 mg NaCl at pH ≅7.0.
分析说明
The biological activity is assayed in tissue culture using mouse fetal liver cells.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
A distinct region in erythropoietin that induces immuno/inflammatory modulation and tissue protection
Yuan RR, et al.
Neurotherapeutics, 12(4), 850-861 (2015)
Erythropoietin use and abuse
John MJ, et al.
Indian Journal of Endocrinology and Metabolism, 16(2), 220-220 (2012)
Recombinant erythropoietin in clinical practice
Ng T, et al.
Postgraduate Medical Journal, 79(933), 367-376 (2003)
Erythropoietin Protects Against Cognitive Impairment and Hippocampal Neurodegeneration in Diabetic Mice
Othman M, et al.
Behavioral Sciences, 9(1), 4-4 (2019)
Functional selectivity in cytokine signaling revealed through a pathogenic EPO mutation
Kim AR, et al.
Cell, 168(6), 1053-1064 (2017)
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