E5627
Erythropoietin 人
recombinant, expressed in CHO cells, lyophilized powder, suitable for cell culture, ~100,000 units/mg protein
别名:
EPO
产品名称
Erythropoietin 人, recombinant, expressed in CHO cells, lyophilized powder, suitable for cell culture, ~100,000 units/mg protein
biological source
human
recombinant
expressed in CHO cells
form
lyophilized powder
specific activity
~100,000 units/mg protein
packaging
pkg of 10UN
technique(s)
cell culture | mammalian: suitable
color
white
UniProt accession no.
storage temp.
−20°C
Quality Level
Gene Information
human ... EPO(2056), EPOR(2057)
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Analysis Note
The biological activity is assayed in tissue culture using mouse fetal liver cells.
Biochem/physiol Actions
Erythropoietin is a glycoprotein that is the principal regulator of red blood cell growth and differentiation.
Erythropoietin (EPO) elicits antiapoptotic, anti-inflammatory and tissue protective functions. EPO is essential for maintaining red blood progenitor cells. It is used for treating hematological disorders and in perioperative therapies. A homozygous mutation in EPO gene obstructs its interaction with receptor and the signaling cascade resulting in severe anemia. Elevated levels of EPO due to mutations is implicated in the pathogenesis of familial erythrocytosis.
Application
Erythropoietin human has been used:
- as a component of cardiac stem cell medium
- to test its neuroprotective effect on diabetic mice
- to test its effect on hippocampal synapses in mice
General description
Erythropoietin is a glycoprotein cytokine and hormone and belongs to the type I cytokine superfamily. It undergoes posttranslational modifications and exists as 18 and 30 kDa molecular weight forms. It is mapped to human chromosome 7q22.
Physical form
Lyophilized as 10 units EPO, 10 mg trisodium citrate and 10 mg NaCl at pH ≅7.0.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
A distinct region in erythropoietin that induces immuno/inflammatory modulation and tissue protection
Yuan RR, et al.
Neurotherapeutics, 12(4), 850-861 (2015)
Concurrent isolation of 3 distinct cardiac stem cell populations from a single human heart biopsy
Monsanto MM, et al.
Circulation Research, 121(2), 113-124 (2017)
Recombinant erythropoietin in clinical practice
Ng T, et al.
Postgraduate Medical Journal, 79(933), 367-376 (2003)
Functional selectivity in cytokine signaling revealed through a pathogenic EPO mutation
Kim AR, et al.
Cell, 168(6), 1053-1064 (2017)
Erythropoietin Protects Against Cognitive Impairment and Hippocampal Neurodegeneration in Diabetic Mice
Othman M, et al.
Behavioral Sciences, 9(1), 4-4 (2019)
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