EGR-1 Protein human

Early Growth Response proteins expressed in insect cells show superior performance in Electrophoretic Mobility Shift Assay (EMSA) compared to proteins expressed in E. coli. May be used for in vitro transcription assays and analysis of nuclear extracts.

Early growth response 1 (EGR-1) may be important in the proliferation of diverse types of cancer cells. It has been used in studies of breast and endometrial cell cancers, and has shown to be an important mediator of signaling in breast and endometrial cancer cells. Therefore, it could be an important target of therapeutic efforts in these cancer types.

EGR (Early Growth Response) proteins represent a family of transcription factors involved in cell cycle regulation. They contain three, nearly identical DNA-binding zinc finger regions, each possessing a unique flanking region. EGR-1, -2, -3, and -4, bind the EGR-consensus sequence GCG T/GGG GCG, however the individual proteins show differing binding affinities.

EGR (Early Growth Response) proteins represent a family of transcription factors involved in cell cycle regulation. They contain three, nearly identical DNA-binding zinc finger regions, each possessing a unique flanking region. EGR-1, -2, -3, and -4 bind the EGR-consensus sequence GCG (T/G)GG GCG, however with differing affinities.

Solution in 20 mM HEPES, 420 mM NaCl, 0.2 mM EDTA, 25% glycerol, and 1.5 mM MgCl_2, pH 7.9.