Anti-EphB1 (ELK Receptor)-EXT antibody produced in sheep

Eph family of tyrosine kinase receptors mediates cell-cell attachment and aggregation by binding to specific ligands, ephrins. The Eph family consists of 14 structurally related receptors that are either membrane linked or are transmembrane with overlapping affinity for ligands. The transmembrane receptors EphA and EphB1 (ELK) subclasses signal via distinct mediators in the cytoplasm. EphB1 binds ephrinB1, recruits Grb2 and Grb10 and mediates cell attachment and cell-cell assembly. Activated EphB1 also reportedly mediates the signaling by c-Jun kinase. The EphB1 receptors are vital in targeting the migration of neurons, angiogenesis and vascular cell assembly during development
Anti-EphB1 (Elk Receptor)-EXT recognizes the external region of human EphB1 protein (116 kDa).

GST-fusion protein EphB1 (Elk Receptor)-EXT corresponding to amino acids 16-351 of the N-terminal region.

Anti- EphB1 (ELK Receptor)-EXT antibody may be used for immunoblotting at a working concentration of 1-10 μg/ml. Antibody concentration of 10-20 μg/ml is recommended for immunoprecipitation.

Solution in phosphate buffered saline with 0.08% sodium azide.

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