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Merck
CN

E7649

Endothall

别名:

7-Oxabicyclo[2.2.1]heptane-2,3-dicarboxylic acid

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关于此项目

经验公式(希尔记法):
C8H10O5
化学文摘社编号:
分子量:
186.16
UNSPSC Code:
12352200
PubChem Substance ID:
EC Number:
205-660-5
MDL number:
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SMILES string

OC(=O)C1[C@@H]2CC[C@@H](O2)C1C(O)=O

Biochem/physiol Actions

Potent inhibitor of phosphatase 2A, IC50 = 90 nM

pictograms

Skull and crossbones

signalword

Danger

Hazard Classifications

Acute Tox. 2 Oral - Acute Tox. 4 Dermal - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 1

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

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Bertrand Faurie et al.
Journal of plant physiology, 166(17), 1863-1877 (2009-07-28)
Perception of elicitors triggers plant defense responses via various early signal transduction pathways. Methyl jasmonate (MeJA) stimulates defense responses in grapevine (Vitis vinifera). We investigated the involvement of various partners (calcium, ROS, reversible phosphorylation) in MeJA-induced responses by using a
R Rakwal et al.
Gene, 263(1-2), 189-198 (2001-02-27)
The Bowman-Birk (BB) family of proteinase inhibitors (PI), initially reported from legume seeds, and thereafter also from wounded alfalfa and maize leaves appear to be regulated in similar ways as the extensively characterized PI I and PI II family from
Alejandra M Yeves et al.
Hypertension (Dallas, Tex. : 1979), 56(4), 690-695 (2010-08-18)
The beneficial effect of phosphodiesterase 5A inhibition in ischemia/reperfusion injury and cardiac hypertrophy is well established. Inhibition of the cardiac Na(+)/H(+) exchanger (NHE-1) exerts beneficial effects on these same conditions, and a possible link between these therapeutic strategies was suggested.
F Erdödi et al.
The American journal of physiology, 269(5 Pt 1), C1176-C1184 (1995-11-01)
The objective of this study was to relate the toxicity of several cantharidin-derivative pesticides with their abilities to inhibit protein phosphatases-1 (PP1) and -2A (PP2A). Cantharidin (CA), endothall, and endothall thioanhydride (ETA) inhibited the activity of PP1 and PP2A, and
G K Agrawal et al.
Biochemical and biophysical research communications, 274(1), 157-165 (2000-07-25)
A novel rice acidic pathogenesis-related (PR) class 1 cDNA (OsPR1a) was isolated from jasmonic acid (JA)-treated rice seedling leaf. The OsPR1a cDNA is 830 bp long and contains an open reading frame of 507 nucleotides encoding 168 amino acid residues

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