biological source
mouse
form
lyophilized powder
potency
10-40 ng/mL
mol wt
~8.2 kDa
packaging
pkg of 20 μg
storage condition
avoid repeated freeze/thaw cycles
UniProt accession no.
storage temp.
−20°C
Gene Information
mouse ... Ccl11(20292)
General description
Eotaxin is a member of the CC chemokine family, and belongs to the MCP/eotaxin subfamily. It has wide range of tissue expression, such as thymus, heart, lungs, lymph nodes, kidney, and intestines. It is also expressed by epithelial cells of lung, pleural mesothelial cells, epithelial cells of bronchial airway, and smooth muscle cells (SMCs). This gene maps to human chromosome 17q21.1-q21.2.
Biochem/physiol Actions
Eotaxin is a chemoattractant for eosinophils, and is involved in inflammatory diseases, such as asthma. It is induced by glucocorticoids and cytokines. Along with interleukin-5 (IL-5), it results in airway hyperresponsiveness (AHR), and hence, lung inflammatory disorders. In humans, it leads to respiratory syncytial virus (RSV) vaccine-enhanced disease, and the eosinophils are also responsible for the elimination of virus. It might also be involved in the pathophysiology of inflammatory bowel diseases, which involve eosinophils. It can lead to the production of reactive oxygen species, thus, resulting in damaged lung tissue. It is overexpressed in multiple diseases such as allergic rhinitis, nasal polyposis, endometriosis and Hodgkin′s disease.
Potent inducer of eosinophil chemotaxis.
Potent inducer of eosinophil chemotaxis. Causes accumulation of eosinophils in response to parasitic and viral reactions.
Other Notes
Mouse sequence biotinylated on the C-terminus.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
P Ogilvie et al.
Blood, 97(7), 1920-1924 (2001-03-27)
Eotaxin is a potent inducer of eosinophil chemotaxis and was considered as a selective ligand of the CC chemokine receptor 3 (CCR3), which is expressed on eosinophils, basophils, and Th2 lymphocytes. This study shows that eotaxin also interacts with CCR2
Ravindra B Kodali et al.
Arteriosclerosis, thrombosis, and vascular biology, 24(7), 1211-1216 (2004-05-08)
CCL11 (Eotaxin) is a potent eosinophil chemoattractant that is abundant in atheromatous plaques. The major receptor for CCL11 is CCR3, which is found on leukocytes and on some nonleukocytic cells. We sought to determine whether vascular smooth muscle cells (SMCs)
E A Garcia-Zepeda et al.
Genomics, 41(3), 471-476 (1997-05-01)
Eotaxin is a CC chemokine that is a specific chemoattractant for eosinophils and is implicated in the pathogenesis of eosinophilic inflammatory diseases, such as asthma. We describe the genomic organization, complete sequence, including 1354 bp 5' of the RNA initiation
M Kitaura et al.
The Journal of biological chemistry, 271(13), 7725-7730 (1996-03-29)
The CC chemokine eotaxin is a selective chemoattractant for guinea pig eosinophils, first purified from bronchoalveolar lavage fluid in a guinea pig model of allergic airway inflammation. We have now isolated the gene and cDNA for a human counterpart of
J Elsner et al.
European journal of immunology, 26(8), 1919-1925 (1996-08-01)
Increased numbers of eosinophils are found in parasitic infections, autoimmune diseases and allergic diseases such as allergic asthma. They are activated by distinct cytokines and chemokines leading to the immigration in the inflamed tissue and mediate tissue damage by releasing
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