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Merck
CN

E8630

Sigma-Aldrich

依托红霉素

别名:

Erythromycin 2′-propionate dodecyl sulfate

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关于此项目

线性分子式:
C40H71NO14 · C12H26SO4
化学文摘社编号:
3521-62-8
分子量:
1056.39
EC 号:
222-532-4
MDL编号:
MFCD00084691
UNSPSC代码:
51101500
PubChem化学物质编号:
24894679

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表单

solid

颜色

white

溶解性

chloroform: 4.0 mL, clear, colorless (200 mg + 4.0 mL Chloroform)

抗生素抗菌谱

Gram-negative bacteria
Gram-positive bacteria

作用机制

protein synthesis | interferes

SMILES字符串

CCCCCCCCCCCCOS(O)(=O)=O.CC[C@H]1OC(=O)[C@@H](C)[C@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@@H](C)[C@H](O[C@@H]3O[C@H](C)C[C@@H]([C@H]3O)N(C)C)[C@@](C)(O)C[C@H](C)C(=O)C(C)[C@@H](O)[C@@]1(C)O

InChI

1S/C37H67NO13.C12H26O4S/c1-14-25-37(10,45)30(41)20(4)27(39)18(2)16-35(8,44)32(51-34-28(40)24(38(11)12)15-19(3)47-34)21(5)29(22(6)33(43)49-25)50-26-17-36(9,46-13)31(42)23(7)48-26;1-2-3-4-5-6-7-8-9-10-11-12-16-17(13,14)15/h18-26,28-32,34,40-42,44-45H,14-17H2,1-13H3;2-12H2,1H3,(H,13,14,15)/t18-,19+,20?,21+,22-,23-,24-,25?,26-,28+,29+,30+,31-,32-,34-,35-,36+,37+;/m0./s1

InChI key

SKDGGFHGLZBNBC-CAHOBLCESA-N

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一般描述

Chemical structure: macrolide

应用

Erythoromycin estolate is used to study hepatic cytochrome P-450 induction and inactivation via cytochrome-metabolite complex formation and Giardia intestinalis inefections. It is used to study antibiotic cytotoxicity in cultured human liver cell lines.

生化/生理作用

Erythromycin inhibits protein synthesis (elongation) at the level of transpeptidation (aminoacyl translocation A-site to P-site) by binding to the 50s subunit of the bacterial 70s rRNA complex.
Erythromycin inhibits protein synthesis (elongation) at the level of transpeptidation (aminoacyl translocation A-site to P-site).

象形图

Health hazardExclamation mark
GHS08,GHS07

警示用语：

Danger

危险声明

H302,H317,H334

危险分类

Acute Tox. 4 Oral - Resp. Sens. 1 - Skin Sens. 1

储存分类代码

11 - Combustible Solids

WGK

WGK 3

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
082K1186
080K1594
051K1554
124F02851
111K1095

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P F Boreham et al.
The Journal of antimicrobial chemotherapy, 16(5), 589-595 (1985-11-01)
The activities of 11 5-nitroimidazole compounds have been compared against Giardia intestinalis in vitro using a 3H-thymidine incorporation assay. All the compounds were at least equipotent to, or more active than metronidazole with the exception of panidazole. Satranidazole, ronidazole and
M Viluksela et al.
The Journal of antimicrobial chemotherapy, 38(3), 465-473 (1996-09-01)
Cytotoxicity of erythromycin base, erythromycin estolate, erythromycin-11,12-cyclic carbonate, roxithromycin, clarithromycin and azithromycin was compared in cultured human non-malignant Chang liver cells using reduction of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide and cellular protein concentration as end points of toxicity. Erythromycin estolate was the
D E Amacher et al.
Antimicrobial agents and chemotherapy, 35(6), 1186-1190 (1991-06-01)
Erythromycin and some other macrolide antibiotics can first induce a cytochrome P-450 isozyme similar to the one induced in rats by pregnenolone-16 alpha-carbonitrile and then inhibit it by forming a stable cytochrome P-450-metabolite complex. The purpose of this study was
L Pari et al.
Pharmacological research, 49(5), 481-486 (2004-03-05)
Tetrahydrocurcumin (THC), one of the major metabolites of curcumin, was investigated for its possible hepatoprotective effect in Wistar rats against erythromycin estolate-induced toxicity. Oral administration of THC significantly prevented the occurrence of erythromycin estolate-induced liver damage. The increased level of
S Venkateswaran et al.
Journal of ethnopharmacology, 57(3), 161-167 (1997-08-01)
Livex, a compound herbal formulation, was investigated for its possible hepatoprotective effect in Wistar rats against erythromycin estolate induced toxicity. Oral administration of Livex significantly prevented the occurrence of erythromycin estolate induced hepatic damage. The increased level of serum enzymes
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