产品名称
抗-E6AP小鼠单克隆抗体, clone E6AP-330, purified from hybridoma cell culture
biological source
mouse
conjugate
unconjugated
antibody form
purified from hybridoma cell culture
antibody product type
primary antibodies
clone
E6AP-330, monoclonal
form
buffered aqueous solution
mol wt
antigen ~100 kDa
species reactivity
human, mouse, rat, monkey
technique(s)
immunocytochemistry: suitable
immunoprecipitation (IP): suitable
indirect ELISA: suitable
microarray: suitable
western blot: 1-2 μg/mL using total cell extract from 293T cells
isotype
IgG1
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... E2F6(1876)
mouse ... E2f6(50496)
rat ... E2f6(313978)
Application
抗-E6AP单克隆抗体适用于western blot（1-2 μg/mL使用来自293T细胞的总细胞提取物）、免疫细胞化学、免疫印迹、免疫沉淀、间接ELISA和微阵列。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
General description
E6AP 是一种 E3 泛素连接酶，由 UB3A 基因表达。UB3A 基因受到抑制或改变可能导致一种名为安格曼综合征的神经系统疾病。E6AP 与 E1 和 E2 酶相互作用，介导标记蛋白质的泛素化并使其酶解。E6AP 还与 HPV 感染细胞中存在的 E6 病毒蛋白结合。
抗 E6AP 单克隆抗体是研究 E6AP 及其在蛋白质酶解中的作用的有用工具。该抗体对大鼠、小鼠、人类和猴子的 E6AP 蛋白具有特异性。
抗 E6AP 单克隆抗体是研究 E6AP 及其在蛋白质酶解中的作用的有用工具。该抗体对大鼠、小鼠、人类和猴子的 E6AP 蛋白具有特异性。
Immunogen
人全长重组E6AP。
Physical form
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
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存储类别
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Lilach Simchi et al.
Journal of clinical medicine, 9(5) (2020-05-28)
The UBE3A gene codes for a protein with two known functions, a ubiquitin E3-ligase which catalyzes ubiquitin binding to substrate proteins and a steroid hormone receptor coactivator. UBE3A is most famous for its critical role in neuronal functioning. Lack of
Yi Sun
Cancer biology & therapy, 2(6), 623-629 (2003-12-23)
E3 ubiquitin ligases are a large family of proteins that can be classified into three major structurally distinct types: N-end rule E3s, E3s containing the HECT (Homology to E6AP C-Terminus) domain, and E3s with the RING (Really Interesting New Gene)
The role of TP53 in Cervical carcinogenesis.
Tommasino, M., et al.
Human Mutation, 21, 307-312 (2003)
Gennaro Altamura et al.
Scientific reports, 8(1), 17529-17529 (2018-12-05)
E6 from high risk human papillomaviruses (HR HPVs) promotes ubiquitination and degradation of p53 tumour suppressor by mediating its binding to ubiquitin ligase E6AP in a ternary complex, contributing to cell transformation in cervical cancer. We have previously shown that
B Dan et al.
Neuropediatrics, 34(4), 169-176 (2003-09-16)
Angelman syndrome is characterised by neurodevelopmental impairment (with or without epileptic seizures) associated with functional deficit of the UBE3A gene. Different mechanisms of UBE3A inactivation correlate with clinical phenotypes of varying severity. However, three distinctive, highly consistent electroencephalographic rhythmic patterns
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