Cytochrome P450 2E1 human

Microsome contains CYP2E1 human and yeast CYP-reductase expressed in Saccharomyces cerevisiae.

Recombinant cytochrome P450, isozyme 2E1, (CYP2E1) may be used in toxicity and drug metabolism/pharmacokinetics research to identify its specificity and activity versus xenobiotic and endogenous compounds. Recombinant cytochrome P450, isozyme 2E1, may be used separately or as a component of a P450 isozyme panel to identify and characterize natural and synthetic selective inhibitors that affect the metabolism of toxic compounds or therapeutic drugs.

50 mM Tris (pH 7,4), 1 mM EDTA, 20% glycerol

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P450 Activity: One unit will oxidize 1 picomole of p-nitrophenol per minute at pH 7.4 at 28 °C.
Reductase Activity: One unit will reduce 1 nanomole of cytochrome C per minute in the presence of NADPH at pH 7.4 at 28 °C.