生物来源
human
质量水平
重组
expressed in Saccharomyces cerevisiae
表单
liquid
比活
≥10 units/pmol enzyme
secondary activity
≥100 units/mg protein (Reductase activity)
浓度
≥10 mg/mL protein (Bradford)
1 pmol/μL
UniProt登记号
应用
cell analysis
运输
dry ice
储存温度
−70°C
基因信息
human ... CYP2D6(1565)
一般描述
Microsome contents of CYP2D6 human and yeast CYP-reductase expressed in Saccharomyces cerevisiae.
应用
Recombinant cytochrome P450, isozyme 2D6, (CYP2D6) may be used in toxicity and drug metabolism/ pharmacokinetics research to identify its specificity and activity versus xenobiotic and endogenous compounds. Recombinant cytochrome P450, isozyme 2D6, may be used separately or as a component of a P450 isozyme panel to identify and characterize natural and synthetic selective inhibitors that affect the metabolism of toxic compounds or therapeutic drugs such as fluoxetine, codeine, and tamoxifen.
外形
50 mM Tris (pH 7.4), 1 mM EDTA, 20% glycerol
其他说明
For more more information visit our drug metabolism resources for Cytochrome P450 microsome preparations.
P450 Activity: One unit will oxidize 1 picomole of dextromethorphan per minute at pH 7.4 at 28 °C.
Reductase Activity: One unit will reduce 1 nanomole of cytochrome C per minute in the presence of NADPH at pH 7.4 at 28 °C.
Reductase Activity: One unit will reduce 1 nanomole of cytochrome C per minute in the presence of NADPH at pH 7.4 at 28 °C.
储存分类代码
12 - Non Combustible Liquids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
此项目有
Clarissa Feltrin et al.
Chemical research in toxicology, 33(9), 2408-2419 (2020-08-14)
The use of medicinal plants concomitantly with conventional drugs can result in herb-drug interactions that cause fluctuations in drug bioavailability and consequent therapeutic failure and/or toxic effects. The CYP superfamily of enzymes plays an important role in herb-drug interactions. Among
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