biological source
baboon plasma
form
solid
mol wt
α-chain 63.5 kDa, β-chain 56 kDa, γ chain 47 kDa (about 4% carbohydrate content), soluble dimer 340 kDa
composition
Protein, ~60% (over 80% of protein clottable)
UniProt accession no.
storage temp.
−20°C
Gene Information
baboon ... FGA(101017602), FGB(101017243), FGG(101017958)
Biochem/physiol Actions
作为蛋白凝血级联系统一部分的急性期蛋白。
纤维蛋白原是一种作为蛋白凝血级联系统一部分的急性期蛋白。级联反应的最终结果是产生凝血酶，凝血酶可将纤维蛋白原转化为纤维蛋白。凝血酶可快速水解纤维蛋白原，从而释放出纤维蛋白肽 A。该小肽的丧失不足以使产生的纤维蛋白分子不溶，但它往往会与邻近的纤维蛋白和纤维蛋白原分子形成复合物。然后凝血酶从纤维蛋白上切下第二条多肽（纤维蛋白肽 B），而后形成的纤维蛋白单体自发聚合，形成不溶性凝胶。聚合的纤维蛋白通过非共价键和静电力结合在一起，并由转氨酶（因子 XIIIa）稳定，而因子 XIIIa 则通过因子 XIII 上凝血酶的作用生成。而后不溶性纤维蛋白聚集物（凝块）和凝集的血小板可阻塞损坏的血管，并阻止进一步出血。血浆中纤维蛋白原的量可作为体内是否存在炎症的非特异性标志。任何哺乳动物来源的纤维蛋白原均可被任何哺乳动物来源的凝血酶裂解。
Analysis Note
Contains ~15% sodium citrate and ~25% sodium chloride.
Protein determined by biuret.
存储类别
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
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