生物来源
sheep
偶联物
unconjugated
抗体形式
fractionated antiserum
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
antigen 52 kDa
种属反应性
human, mouse
技术
western blot: suitable using whole extracts from mouse erythroleukemia cell lines, DP16-1 and CB7 and human T-cell line.
UniProt登记号
运输
dry ice
储存温度
−20°C
基因信息
human ... FLI1(2313)
mouse ... Fli1(14247)
免疫原
GST fusion protein of the N-terminus of Fli-1 corresponding to amino acids 1-239.
应用
Anti-FLI-1 antibody produced in sheep is suitable for western blotting using whole extracts from mouse erythroleukemia cell lines, DP16-1 and CB7 and human T-cell line.
生化/生理作用
Friend leukemia integration 1 transcription factor (FLI1) is a protein that is encoded by the FLI1 gene in humans and is a member of Ets transcription factor family. It is a proto-oncogene and located on human chromosome 11q23-24. FLI1 may be involved in human sarcomas, leukemias and lymphomas. It may play an important role in the posttranscriptional regulation of the Fli-1 transcript. Alteration in the transcriptional activation function of Fli-1 may be responsible for human malignancies. It is a novel ETS transcription factor involved in gene fusions in prostate cancer.
外形
Solution in 0.01 M phosphate buffered saline, containing 0.08% sodium azide
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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V N Rao et al.
Oncogene, 8(8), 2167-2173 (1993-08-01)
Three of the ets oncogene superfamily members v-ets, Spi-1/PU.1 and Fli-1, have been shown to be directly involved in retroviral-mediated acute erythroleukemias. The Fli-1 gene was found to be rearranged in 75% of the erythroleukemias induced by Friend murine leukemia
D D Prasad et al.
Cancer research, 52(20), 5833-5837 (1992-10-15)
Three ets family members, v-ets, spleen focus forming virus proviral integration 1/Pu.1, and Friend leukemia integration 1 (Fli-1), were shown to be involved in retroviral mediated acute leukemias suggesting that ets family members play a crucial role in transformation. Mouse
Paula Paulo et al.
Genes, chromosomes & cancer, 51(3), 240-249 (2011-11-15)
To characterize the pattern of ETS rearrangements and to uncover novel ETS fusion genes, we analyzed 200 prostate carcinomas (PCa) with TaqMan low-density arrays (TLDAs), followed by selective analyses with fluorescence in situ hybridization (FISH), RT-PCR, and sequencing. Besides confirming
Steven M Kornblau et al.
Blood, 118(20), 5604-5612 (2011-09-16)
Friend leukemia virus integration 1 (FLI1), an Ets transcription factor family member, is linked to acute myelogenous leukemia (AML) by chromosomal events at the FLI1 locus, but the biologic impact of FLI1 expression on AML is unknown. FLI1 protein expression
V Baud et al.
Genomics, 11(1), 223-224 (1991-09-01)
FLI1 is a common mouse viral integration region in virus-induced leukemias and lymphomas. Using an evolutionarily conserved mouse probe and Southern hybridization to (rodent x human) somatic cell hybrid DNAs, the human homolog of FLI1 has been shown to lie
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