F113
R(−)-氟苯丙胺 盐酸盐
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关于此项目
经验公式（希尔记法）:
C12H16F3N · HCl
化学文摘社编号:
分子量:
267.72
UNSPSC Code:
12352116
PubChem Substance ID:
MDL number:
InChI
1S/C12H16F3N.ClH/c1-3-16-9(2)7-10-5-4-6-11(8-10)12(13,14)15;/h4-6,8-9,16H,3,7H2,1-2H3;1H/t9-;/m1./s1
SMILES string
Cl.CCN[C@H](C)Cc1cccc(c1)C(F)(F)F
InChI key
ZXKXJHAOUFHNAS-SBSPUUFOSA-N
drug control
USDEA Schedule IV
Biochem/physiol Actions
Neurotoxic on prolonged administration or at high dosage; releases serotonin from axon terminals by a nonexocytotic mechanism; anorectic.
活性较低的对映体
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
法规信息
监管及禁止进口产品
此项目有
Recent studies in the clinical pharmacology of anorectic drugs.
Silverstone, et al.
Recent Adv. Obes. Res., 5, 285-285 (1986)
Re: Estimate of deaths due to valvular insufficiency attributable to the use of benfluorex in France.
Nicolas Deltour et al.
Pharmacoepidemiology and drug safety, 21(6), 584-585 (2012-04-21)
Enhanced behavioral response to serotonin-related agonists in postweaning protein malnourished mice.
Shoko Sato et al.
Biological & pharmaceutical bulletin, 35(10), 1697-1702 (2012-08-02)
We investigated whether postweaning protein malnutrition (PM) affects serotonergic systems. Mice were fed a PM diet or normal protein (control) diet from weaning (21 d of age). Twenty days later, we tested for behavioral effects of the selective serotonin (5-HT)(1A)
Benfluorex-induced cardiac valve injury.
Jean Acar
Pharmacoepidemiology and drug safety, 21(11), 1243-1244 (2012-10-31)
Laurent Savale et al.
The European respiratory journal, 40(5), 1164-1172 (2012-04-24)
Benfluorex was marketed in France until 2009, despite its similar pharmacological properties with fenfluramine and its derivatives known to be a cause of pulmonary arterial hypertension (PAH). The aim of this study is to report clinical and haemodynamic characteristics for
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