F1179
FPL-55712
≥97% (HPLC), solid
别名:
7-[3-(4-Acetyl-3-hydroxy-2-propylphenoxy)-2-hydroxypropoxy]- 4-oxo-8-propyl-4H-1-benzopyran-2-carboxylic acid sodium salt
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关于此项目
经验公式（希尔记法）:
C27H29O9Na
化学文摘社编号:
分子量:
520.50
MDL编号:
UNSPSC代码:
12352202
PubChem化学物质编号:
NACRES:
NA.77
方案
≥97% (HPLC)
表单
solid
颜色
off-white
mp
150-160 °C
溶解性
H2O: ≥15 mg/mL, clear, yellow
储存温度
−20°C
SMILES字符串
[Na+].CCCc1c(O)c(ccc1OCC(O)COc2ccc3C(=O)C=C(Oc3c2CCC)C([O-])=O)C(C)=O
InChI
1S/C27H30O9.Na/c1-4-6-19-22(10-8-17(15(3)28)25(19)31)34-13-16(29)14-35-23-11-9-18-21(30)12-24(27(32)33)36-26(18)20(23)7-5-2;/h8-12,16,29,31H,4-7,13-14H2,1-3H3,(H,32,33);/q;+1/p-1
InChI key
ZDEVPOBNLIVGFA-UHFFFAOYSA-M
生化/生理作用
CysLT1 leukotriene receptor antagonist.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
N Nakagawa et al.
European journal of pharmacology, 235(2-3), 211-219 (1993-04-28)
Peptide leukotrienes have been suggested to play an important role in bronchial asthma. As antigen-induced bronchoconstrictions, airway hyperreactivity, and pulmonary eosinophil accumulation are characteristics of the pathology of asthma, we investigated the effect of a peptide leukotriene receptor antagonist, ONO-1078
B J Hopkins et al.
Toxicon : official journal of the International Society on Toxinology, 32(10), 1197-1210 (1994-10-01)
The present study was designed to examine some of the pharmacological properties of venom from the stonefish (Synanceja trachynis), with particular reference to the presence in the venom of pain-producing/enhancing substances. Stonefish venom (1-6 micrograms/ml) produced concentration-dependent contractile responses in
C M Rodríguez-Ortigosa et al.
Gastroenterology, 108(6), 1793-1801 (1995-06-01)
Cysteinyl-containing leukotrienes seem to exert a cholestatic effect. However, leukotriene inhibitors were found to reduce bile salt efflux in isolated rat hepatocytes, suggesting a role for leukotrienes in bile flow formation. In the isolated rat liver, the effects of two
M Pfeifer et al.
Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie, 197(4), 177-187 (1997-01-01)
The pathophysiological role of endogenous leukotrienes in cardiovascular control and the regulation of renal function in congestive heart failure is not known. Therefore, in six conscious dogs with or without heart failure induced by right ventricular pacing (270/min, 10 days)
T Obata et al.
Life sciences, 52(12), PL97-P102 (1993-01-01)
The effect of a peptide leukotriene receptor antagonist ONO-1078 on the production of thromboxane (Tx) B2 induced by leukotriene (LT) D4 and antigen challenge was examined in guinea pig lungs. LTD4 (1-1,000 nM) induced a concentration-dependent production of TxB2 in
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