F1179
FPL-55712
≥97% (HPLC), solid
别名:
7-[3-(4-Acetyl-3-hydroxy-2-propylphenoxy)-2-hydroxypropoxy]- 4-oxo-8-propyl-4H-1-benzopyran-2-carboxylic acid sodium salt
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关于此项目
经验公式（希尔记法）:
C27H29O9Na
化学文摘社编号:
分子量:
520.50
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352202
MDL number:
Assay:
≥97% (HPLC)
Form:
solid
InChI
1S/C27H30O9.Na/c1-4-6-19-22(10-8-17(15(3)28)25(19)31)34-13-16(29)14-35-23-11-9-18-21(30)12-24(27(32)33)36-26(18)20(23)7-5-2;/h8-12,16,29,31H,4-7,13-14H2,1-3H3,(H,32,33);/q;+1/p-1
SMILES string
[Na+].CCCc1c(O)c(ccc1OCC(O)COc2ccc3C(=O)C=C(Oc3c2CCC)C([O-])=O)C(C)=O
InChI key
ZDEVPOBNLIVGFA-UHFFFAOYSA-M
assay
≥97% (HPLC)
form
solid
color
off-white
mp
150-160 °C
solubility
H2O: ≥15 mg/mL, clear, yellow
storage temp.
−20°C
Biochem/physiol Actions
CysLT1 leukotriene receptor antagonist.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
Leukotriene cysLT1 (LTD4) receptor antagonism of H1-antihistamines: an in vitro study.
M Q Zhang et al.
Inflammation research : official journal of the European Histamine Research Society ... [et al.], 46 Suppl 1, S93-S94 (1997-03-01)
T Obata et al.
Life sciences, 52(12), PL97-P102 (1993-01-01)
The effect of a peptide leukotriene receptor antagonist ONO-1078 on the production of thromboxane (Tx) B2 induced by leukotriene (LT) D4 and antigen challenge was examined in guinea pig lungs. LTD4 (1-1,000 nM) induced a concentration-dependent production of TxB2 in
Role of eicosanoid inhibition of ischemia reperfusion injury: intact and isolated rat heart studies.
A Shekher et al.
Methods and findings in experimental and clinical pharmacology, 19(4), 223-229 (1997-05-01)
The effects of FPL-55712 (leukotriene receptor antagonist) and OKY-046 (thromboxane synthase inhibitor) were studied on ischemic and reperfused myocardium using in vivo and in vitro rat heart paradigms. The in vivo studies included production of regional ischemia by coronary artery
C M Rodríguez-Ortigosa et al.
Gastroenterology, 108(6), 1793-1801 (1995-06-01)
Cysteinyl-containing leukotrienes seem to exert a cholestatic effect. However, leukotriene inhibitors were found to reduce bile salt efflux in isolated rat hepatocytes, suggesting a role for leukotrienes in bile flow formation. In the isolated rat liver, the effects of two
B J Hopkins et al.
Toxicon : official journal of the International Society on Toxinology, 32(10), 1197-1210 (1994-10-01)
The present study was designed to examine some of the pharmacological properties of venom from the stonefish (Synanceja trachynis), with particular reference to the presence in the venom of pain-producing/enhancing substances. Stonefish venom (1-6 micrograms/ml) produced concentration-dependent contractile responses in
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