F133
Norfluoxetine hydrochloride
≥97%, solid
别名:
(±)-γ-(4-Trifluoromethylphenoxy)benzenepropanamine hydrochloride
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关于此项目
经验公式（希尔记法）:
C16H16F3NO · HCl
化学文摘社编号:
分子量:
331.76
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
应用
Norfluoxetine hydrochloride has been used to examine if psychoactive pharmaceuticals in drinking water at environmental concentrations could induce neuronal gene expression. It has also been used to examine whether at environmental concentrations it can alter in vitro expression of autism spectrum disorders (ASD)-associated synaptic proteins in human neurons.
生化/生理作用
Fluoxetine metabolite; more potent inhibitor of serotonin uptake than fluoxetine with a half-life in vivo of 5-7 days.
Norfluoxetine is an active metabolite of fluoxetine. It disturbs the production of estrogen in a co-culture model of the feto-placental unit.
法律信息
经 Eli Lilly and Company 授权销售。
免责声明
Hygroscopic, photosensitive
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Jun Zuo et al.
Antimicrobial agents and chemotherapy, 56(9), 4838-4844 (2012-07-04)
No antiviral drugs currently exist for the treatment of enterovirus infections, which are often severe and potentially life threatening. Molecular screening of small molecule libraries identified fluoxetine, a selective serotonin reuptake inhibitor, as a potent inhibitor of coxsackievirus replication. Fluoxetine
D T Wong et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 8(4), 337-344 (1993-06-01)
Like fluoxetine, the N-demethylated metabolite norfluoxetine exists in R- and S-enantiomeric forms. S-Norfluoxetine inhibited serotonin (5-HT) uptake and [3H]paroxetine binding to 5-HT uptake sites with a pKi of 7.86 and 8.88 or 14 and 1.3 nM, respectively, whereas R-norfluoxetine was
Victoria K H Barclay et al.
Journal of chromatography. A, 1227, 105-114 (2012-01-24)
The isotope-labeled compounds fluoxetine-d₅ and norfluoxetine-d₅ were used to study matrix effects caused by co-eluting compounds originating from raw and treated wastewater samples, collected in Uppsala, Sweden. The matrix effects were investigated by the determination of matrix factors (MF) and
W Abdel-Razaq et al.
Neurochemical research, 36(2), 327-338 (2010-12-02)
The in vitro effects of antidepressant drugs on mitochondrial function were investigated in a CHOβ(2)SPAP cell line used previously to determine the effects of antidepressants on gene transcription (Abdel-Razaq et al., Biochem Pharmacol 73:1995-2003, 2007) and in rat heart isolated
Robert K McNamara et al.
Progress in neuro-psychopharmacology & biological psychiatry, 34(7), 1317-1321 (2010-07-27)
Omega-3 (n-3) polyunsaturated fatty acids (PUFA) and fluoxetine (FLX) have additive effects in the treatment of major depressive disorder, and FLX up-regulates genes that regulate fatty acid biosynthesis in vitro. Although these data suggest that FLX may augment n-3 fatty
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