F2681
Anti-PFKFB3 (472-484) antibody produced in rabbit
IgG fraction of antiserum, buffered aqueous solution
别名:
Anti-6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3, Anti-IPFK2, Anti-PFK2
生物来源
rabbit
偶联物
unconjugated
抗体形式
IgG fraction of antiserum
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
antigen ~60 kDa
种属反应性
human
技术
western blot: 1:500-1:2,000
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... PFKFB3(5209)
免疫原
synthetic peptide corresponding to amino acids 472-484 of human PFKFB3.
应用
Anti-PFKFB3 (472-484) antibody is suitable for western blot analysis at a dilution of 1:500-1:2,000.
Yale Center for High Throughput Cell Biology IF-tested antibodies. Each antibody is tested by immunofluorescence against HUVEC cells using the Yale HTCB IF protocol. To learn more about us and Yale Center for High Throughput Cell Biology partnership, visit sigma.com/htcb-if.
Yale Center for High Throughput Cell Biology IF-tested antibodies. Each antibody is tested by immunofluorescence against HUVEC cells using the Yale HTCB IF protocol. To learn more about us and Yale Center for High Throughput Cell Biology partnership, visit sigma.com/htcb-if.
生化/生理作用
PFKFB3 is ubiquitously present in nucleus of proliferating tissues, transformed cells, in various solid tumours and astrocytomas. In mammals, four types of PFKFB genes have been identified such as PFKFB1, PFKFB2, PFKFB3 and PFKFB4 which encode for the different PFK-2/FBPase-2 isoenzymes. Their characterization depends on the tissue expression pattern. PFKFB3 is associated with cell proliferation in carbohydrate metabolism.It has the highest PFK-2/FBPase-2 activity ratio.
外形
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
未找到合适的产品？
试试我们的产品选型工具.
法规信息
新产品
此项目有
Laura Novellasdemunt et al.
The Biochemical journal, 452(3), 531-543 (2013-04-04)
PFK-2/FBPase-2 (6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase) catalyses the synthesis and degradation of Fru-2,6-P2 (fructose 2,6-bisphosphate), a key modulator of glycolysis and gluconeogenesis. The PFKFB3 gene is involved in cell proliferation owing to its role in carbohydrate metabolism. In the present study we analysed the
Abdullah Yalcin et al.
The Journal of biological chemistry, 284(36), 24223-24232 (2009-05-29)
The regulation of metabolism and growth must be tightly coupled to guarantee the efficient use of energy and anabolic substrates throughout the cell cycle. Fructose 2,6-bisphosphate (Fru-2,6-BP) is an allosteric activator of 6-phosphofructo-1-kinase (PFK-1), a rate-limiting enzyme and essential control
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持