F5013
5-氟乳清酸 水合物
≥98%
别名:
2,6-二羟基-5-氟嘧啶-4-羧酸, 5-氟尿嘧啶-4-羧酸
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关于此项目
经验公式（希尔记法）:
C5H3FN2O4 · xH2O
化学文摘社编号:
分子量:
174.09 (anhydrous basis)
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352204
EC Number:
211-876-0
MDL number:
产品名称
5-氟乳清酸 水合物, ≥98%
InChI key
LODRRYMGPWQCTR-UHFFFAOYSA-N
InChI
1S/C5H3FN2O4.H2O/c6-1-2(4(10)11)7-5(12)8-3(1)9;/h(H,10,11)(H2,7,8,9,12);1H2
SMILES string
OC(C(NC(N1)=O)=C(F)C1=O)=O.[H]O[H]
biological source
synthetic
assay
≥98%
form
powder
technique(s)
cell culture | plant: suitable
mp
278 °C (dec.) (lit.)
solubility
4 M NH4OH: 50 mg/mL, clear, colorless to light yellow
storage temp.
−20°C
Quality Level
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Application
5-氟乳清酸水合物也已用作反向筛选剂，用于筛选乳酸乳球菌（多种）肽酶敲除突变体和白色念珠菌。它已用于合成5-氟乳清苷5′-单磷酸(FOMP)。
可用于选择酿酒酵母的乳清苷-5′-磷酸脱羧酶突变体。
Biochem/physiol Actions
5-氟乳清酸是哺乳动物中rRNA合成的选择性抑制剂。
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Inhibition of ribosomal ribonucleic acid maturation in rat liver by 5-fluoroorotic acid resulting in the selective labeling of cytoplasmic messenger ribonucleic acid
Wilkinson D S, et al.
The Journal of Biological Chemistry, 246(21), 6418-6427 (1971)
Chenxi Huang et al.
Applied and environmental microbiology, 86(18) (2020-07-19)
Large-scale mass spectrometry-based peptidomics for bioactive-peptide discovery is relatively unexplored because of challenges in intracellular peptide extraction and small-peptide identification. Here, we present an analytical pipeline for large-scale intracellular peptidomics of Lactococcus lactis It entails an optimized sample preparation protocol
Mechanism of the orotidine 5?-monophosphate decarboxylase-catalyzed reaction: Effect of solvent viscosity on kinetic constants
Wood B M, et al.
Biochemistry, 48(24), 5510-5517 (2009)
Lakshmi Sreekumar et al.
Genetics, 212(4), 1121-1132 (2019-05-31)
The diploid budding yeast Candida albicans harbors unique CENPA-rich 3- to 5-kb regions that form the centromere (CEN) core on each of its eight chromosomes. The epigenetic nature of these CENs does not permit the stabilization of a functional kinetochore
Jiaxin Gao et al.
Nature communications, 9(1), 4495-4495 (2018-10-31)
Fungal infections by drug-resistant Candida albicans pose a global public health threat. However, the pathogen's diploid genome greatly hinders genome-wide investigations of resistance mechanisms. Here, we develop an efficient piggyBac transposon-mediated mutagenesis system using stable haploid C. albicans to conduct
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