F6550
Anti-FLIPα, C-Terminal antibody produced in rabbit
IgG fraction of antiserum, buffered aqueous solution
别名:
Anti-CASH, Anti-CLARP, Anti-Casper, Anti-FLAME-1, Anti-I-FLICE
biological source
rabbit
conjugate
unconjugated
antibody form
IgG fraction of antiserum
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 55 kDa
species reactivity
human
technique(s)
western blot: 0.5 μg/mL using human HeLa cell extract
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... CFLAR(8837)
Immunogen
synthetic peptide corresponding to amino acids 447-464 of human FLIPα/FLIPL.
Application
Anti-FLIPα, C-Terminal antibody is suitable for:
- western blotting of whole L540 cell extracts to detect c-flip activity in the regulation of NF-κB distribution and activity by 5F11 and bortezomib
- immunohistochemistry analysis to study the optimization of c-FLIP activity in lymphoma cells
- immunohistochemical cytoplasmic c-Flip staining to detect c-FLIP expression in Burkitt′s lymphoma (BL) may be a reliable prognostic marker
- western blot analysis at a concentration of 0.5μg/mL using human HeLa cell extract.
Biochem/physiol Actions
By immunoblotting, the antibody detects human FLIPα (FLICE-inhibitory protein).
Physical form
Solution in phosphate buffered saline containing 0.02% sodium azide
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
The fully human anti-CD30 antibody 5F11 activates NF-?B and sensitizes lymphoma cells to bortezomib-induced apoptosis.
Boris B et al.
Blood, 106(5) (2005)
Marie-Blanche Valnet-Rabier et al.
British journal of haematology, 128(6), 767-773 (2005-03-10)
The World Health Organization Classification of Lymphoid Neoplasms identifies Burkitt's lymphoma/leukaemia (BL) as a single entity, characterized by unique clinical and genetic features that require specific high intensity chemotherapy regimens. Although remarkable successes in the treatment of the disease have
I S van Houdt et al.
Histopathology, 51(6), 778-784 (2007-11-29)
Inhibition of apoptosis is important in the pathogenesis of lymphomas. c-FLIP, a regulator of caspase 8-mediated apoptosis, plays an important role in protecting normal B and T cells from apoptosis and possibly also in lymphomas. Because of contradictory reports about
Teruki Yanagi et al.
PloS one, 10(3), e0119404-e0119404 (2015-03-20)
While PCTAIRE1/PCTK1/Cdk16 is overexpressed in malignant cells and is crucial in tumorigenesis, its function in apoptosis remains unclear. Here we investigated the role of PCTAIRE1 in apoptosis, especially in the extrinsic cell death pathway. Gene-knockdown of PCTAIRE1 sensitized prostate cancer
Ines Müller et al.
Molecular cell, 77(5), 970-984 (2020-01-27)
Cytosolic caspase-8 is a mediator of death receptor signaling. While caspase-8 expression is lost in some tumors, it is increased in others, indicating a conditional pro-survival function of caspase-8 in cancer. Here, we show that tumor cells employ DNA-damage-induced nuclear
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