F6807
氟罗沙星
别名:
6,8-二氟-1-(2-氟乙基)1,4-二氢-7-(4-甲基-1-哌嗪基)-4-氧代-3-喹啉羧酸, 6,8-二氟-1-(2-氟乙基)1,4-二氢-7-(4-甲基哌嗪)-4-氧代-3-喹啉羧酸, AM-833, 多氟哌酸, 多氟沙星
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经验公式（希尔记法）:
C17H18F3N3O3
化学文摘社编号:
分子量:
369.34
NACRES:
NA.85
PubChem Substance ID:
UNSPSC Code:
51102829
MDL number:
InChI
1S/C17H18F3N3O3/c1-21-4-6-22(7-5-21)15-12(19)8-10-14(13(15)20)23(3-2-18)9-11(16(10)24)17(25)26/h8-9H,2-7H2,1H3,(H,25,26)
SMILES string
CN1CCN(CC1)c2c(F)cc3C(=O)C(=CN(CCF)c3c2F)C(O)=O
InChI key
XBJBPGROQZJDOJ-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
solid
color
white to off-white
solubility
0.1 M NaOH: 10 mg/mL
antibiotic activity spectrum
Gram-negative bacteria, Gram-positive bacteria, mycobacteria, mycoplasma
mode of action
DNA synthesis | interferes, enzyme | inhibits
storage temp.
−20°C
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Application
Fleroxacin is a broad-spectrum antimicrobial fluoroquinolone. It is used in pharmacokinetic studies and is used to study the treatment of intra-abdominal abscesses and travellers′ diarrhea.
Biochem/physiol Actions
Fleroxacin is a synthetic trifluorinated quinolone with antimicrobial activity against a variety of pathogens, including mycobacteria, mycoplasmas, chlamydiae, and legionellae. It strongly inhibits the DNA-supercoiling activity of DNA gyrase and DNA topoisomerase 2, which results in cell death.
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
A Pefanis et al.
Antimicrobial agents and chemotherapy, 38(2), 252-255 (1994-02-01)
To assess the potential efficacy of fleroxacin in combination with clindamycin or metronidazole in mixed aerobic and anaerobic infections, we used a rat model of intra-abdominal abscesses in which the inoculum consisted of pooled rat feces mixed with BaSO4. Two
R Steffen et al.
The Journal of antimicrobial chemotherapy, 31(5), 767-776 (1993-05-01)
A double-blind, randomized, placebo-controlled trial was conducted to evaluate the efficacy and safety of fleroxacin for one or two days as treatment for patients with travellers' diarrhoea. A total of 195 patients who were suffering with acute diarrhoea of less
J C Akaniro et al.
Antimicrobial agents and chemotherapy, 34(10), 1880-1884 (1990-10-01)
We evaluated fleroxacin, a newer fluoroquinolone, against isolates from sputum from patients with cystic fibrosis. These isolates included rough and mucoid Pseudomonas aeruginosa, Pseudomonas cepacia, Staphylococcus aureus, Haemophilus influenzae, and Escherichia coli. Selected isolates were tested by the broth microdilution
Xiaozhang Zhu et al.
Journal of the American Chemical Society, 133(41), 16342-16345 (2011-09-22)
A heptacyclic carbocycle possessing three p-quinodimethane units conjugated in one plane has been synthesized and shown to exhibit distinct biradical characteristics. The molecule has a HOMO/LUMO band gap of ca. 1 eV and a S(0)-T(1) energy gap of 2.12 kcal/mol
Benjamin Waibel et al.
Journal of pharmaceutical and biomedical analysis, 43(5), 1595-1601 (2007-01-27)
In order to investigate and characterize interaction processes between the fluoroquinolone fleroxacin and bacterial cells we used non-selective (all resonances are excited), selective (observed resonance is excited) spin-lattice relaxation rates and spin-spin relaxation measurements. The signals of three hydrogens at
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