F8182
法罗培南钠 水合物
≥98% (HPLC)
别名:
(5R,6S,8R,2′R)-2-(2′-四氢呋喃基)-6-羟乙基青霉烯-3-羧酸钠盐, ALP 201, SUN 5555, SY 5555, Wy 49605, 呋罗培南, 法罗培南, 法罗培南钠片
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关于此项目
经验公式（希尔记法）:
C12H14NNaO5S · xH2O
化学文摘社编号:
分子量:
307.30 (anhydrous basis)
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
质量水平
方案
≥98% (HPLC)
表单
powder
旋光性
[α]/D +120 to +130°, c = 1.0 in water
储存条件
desiccated
颜色
white to light brown
溶解性
H2O: ≥20 mg/mL
创始人
Daiichi-Sankyo
储存温度
−20°C
SMILES字符串
O.[Na+].C[C@@H](O)C1C2SC(C3CCCO3)=C(N2C1=O)C([O-])=O
InChI
1S/C12H15NO5S.Na.H2O/c1-5(14)7-10(15)13-8(12(16)17)9(19-11(7)13)6-3-2-4-18-6;;/h5-7,11,14H,2-4H2,1H3,(H,16,17);;1H2/q;+1;/p-1/t5-,6-,7+,11-;;/m1../s1
InChI key
FHSVCMPZCIOKGW-VIDQLUEFSA-M
一般描述
法罗培南钠水合物属于口服处方的青霉类抗生素。具有头孢菌素抗性的肠杆菌科细菌感染易受法罗培南的影响。法罗培南可能是治疗由广谱β-内酰胺酶（ESBL）产生细菌引起的尿路感染的一种有效的抗生素。
生化/生理作用
属于培南类的光谱β-内酰胺抗生素；β-内酰胺酶稳定。
法罗培南钠是一种超广谱、耐受β-内酰胺酶的β-内酰胺抗生素，对革兰氏阳性和革兰氏阴性细菌均具有活性。
特点和优势
该化合物由Daiichi-Sankyo开发。要浏览其他药物开发化合物和批准的药物/候选药物列表，单击此处。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
此项目有
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Activity of faropenem against cephalosporin-resistant Enterobacteriaceae.
Mushtaq S, et al.
The Journal of Antimicrobial Chemotherapy, 59(5), 1025-1030 (2007)
D Sewell et al.
Antimicrobial agents and chemotherapy, 39(7), 1591-1595 (1995-07-01)
The in vitro activity of WY-49605 (SUN5555) (WY) was compared with those of cefaclor, cefixime, and amoxicillin-clavulanic acid against 2,958 consecutive clinical isolates from five medical centers and 402 respiratory pathogens from 18 other facilities. Most members of the family
J E Mortensen et al.
Diagnostic microbiology and infectious disease, 22(3), 301-306 (1995-07-01)
The in vitro activity of the oral penem furopenem (WY-49605, 545555, SUN5555, and ALP201) was tested against clinical bacteria isolated from pediatric patients. Furopenem was compared with clarithromycin, cefpodoxime, amoxicillin, amoxicillin-clavulanate, cefaclor, cefixime, and cefuroxime. Furopenem demonstrated consistent activity against
Y Harada et al.
The Japanese journal of antibiotics, 48(2), 261-270 (1995-02-01)
SY5555 is a new oral penem antibiotic. Pharmacokinetic and clinical studies using SY5555 dry syrup (powder which is dissolved before use) were performed in pediatric patients. 1. Pharmacokinetic investigation Peak plasma concentrations of SY5555 after dose of 5 mg/kg, 10
J M Woodcock et al.
The Journal of antimicrobial chemotherapy, 39(1), 35-43 (1997-01-01)
The in-vitro activity of faropenem, a novel oral penem, was studied in comparison with other beta-lactam antimicrobials against 711 recent clinical isolates including Gram-negative, Gram-positive and anaerobic bacteria. MIC data showed that faropenem was active against most members of the
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Bioactive small molecules for immune system signaling target identification/validation and antibiotics, antivirals, and antifungals offered.
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