F8182
法罗培南钠 水合物
≥98% (HPLC)
别名:
(5R,6S,8R,2′R)-2-(2′-四氢呋喃基)-6-羟乙基青霉烯-3-羧酸钠盐, ALP 201, SUN 5555, SY 5555, Wy 49605, 呋罗培南, 法罗培南, 法罗培南钠片
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关于此项目
经验公式（希尔记法）:
C12H14NNaO5S · xH2O
化学文摘社编号:
分子量:
307.30 (anhydrous basis)
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
产品名称
法罗培南钠 水合物, ≥98% (HPLC)
InChI
1S/C12H15NO5S.Na.H2O/c1-5(14)7-10(15)13-8(12(16)17)9(19-11(7)13)6-3-2-4-18-6;;/h5-7,11,14H,2-4H2,1H3,(H,16,17);;1H2/q;+1;/p-1/t5-,6-,7+,11-;;/m1../s1
SMILES string
O.[Na+].C[C@@H](O)C1C2SC(C3CCCO3)=C(N2C1=O)C([O-])=O
InChI key
FHSVCMPZCIOKGW-VIDQLUEFSA-M
assay
≥98% (HPLC)
form
powder
optical activity
[α]/D +120 to +130°, c = 1.0 in water
storage condition
desiccated
color
white to light brown
solubility
H2O: ≥20 mg/mL
originator
Daiichi-Sankyo
storage temp.
−20°C
Quality Level
Biochem/physiol Actions
属于培南类的光谱β-内酰胺抗生素；β-内酰胺酶稳定。
法罗培南钠是一种超广谱、耐受β-内酰胺酶的β-内酰胺抗生素，对革兰氏阳性和革兰氏阴性细菌均具有活性。
Features and Benefits
该化合物由Daiichi-Sankyo开发。要浏览其他药物开发化合物和批准的药物/候选药物列表，单击此处。
General description
法罗培南钠水合物属于口服处方的青霉类抗生素。具有头孢菌素抗性的肠杆菌科细菌感染易受法罗培南的影响。法罗培南可能是治疗由广谱β-内酰胺酶（ESBL）产生细菌引起的尿路感染的一种有效的抗生素。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
S K Spangler et al.
Antimicrobial agents and chemotherapy, 38(11), 2599-2604 (1994-11-01)
The National Committee for Clinical Laboratory Standards agar dilution method was used to compare the in vitro activity of WY-49605 (also called SUN/SY 5555 and ALP-201), a new broad-spectrum oral penem, to those of amoxicillin, amoxicillin-clavulanate, imipenem, ciprofloxacin, cefaclor, cefpodoxime
S Furukawa et al.
The Japanese journal of antibiotics, 48(2), 210-219 (1995-02-01)
1. SY5555 dry syrup (powder which is dissolved before use) was administered to 25 patients with bacterial infections (6 cases of bronchitis, 2 cases of bronchopneumonia, 1 case of pertussis, 3 cases of scarlet fever, 5 cases of tonsillitis, 3
Faropenem, a new oral penem: antibacterial activity against selected anaerobic and fastidious periodontal isolates.
Milazzo I, et al.
The Journal of Antimicrobial Chemotherapy, 51(3), 721-725 (2003)
Treatment of acute uncomplicated cystitis with faropenem for 3 days versus 7 days: multicentre, randomized, open-label, controlled trial.
Hamasuna R, et al.
The Journal of Antimicrobial Chemotherapy, 69(6), 1675-1680 (2014)
T Motohiro et al.
The Japanese journal of antibiotics, 48(2), 238-260 (1995-02-01)
Pharmacokinetic, bacteriological and clinical studies on SY5555, a new oral penem, were carried out, and the following results were obtained. 1. MICs were determined for 6 drugs, SY5555, clavulanic acid/amoxicillin (CVA/AMPC), cefaclor (CCL), cefotiam (CTM), cefpodoxime (CPDX), cefdinir (CFDN) against
商品
Bioactive small molecules for immune system signaling target identification/validation and antibiotics, antivirals, and antifungals offered.
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