F8507
(+)-芬氟拉明 盐酸盐
别名:
(±)-N-Ethyl-α-methyl-m-[trifluoromethyl]phenethylamine hydrochloride
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关于此项目
经验公式（希尔记法）:
C12H16F3N · HCl
化学文摘社编号:
分子量:
267.72
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
drug control
USDEA Schedule IV
application(s)
forensics and toxicology
SMILES string
Cl.CCNC(C)Cc1cccc(c1)C(F)(F)F
InChI
1S/C12H16F3N.ClH/c1-3-16-9(2)7-10-5-4-6-11(8-10)12(13,14)15;/h4-6,8-9,16H,3,7H2,1-2H3;1H
InChI key
ZXKXJHAOUFHNAS-UHFFFAOYSA-N
Gene Information
human ... HTR1D(3352), HTR2C(3358), SIGMAR1(10280)
Biochem/physiol Actions
Neurotoxic on prolonged administration or at high dosage; releases serotonin from axon terminals by a nonexocytotic mechanism; anorectic
signalword
Danger
hcodes
pcodes
Hazard Classifications
Acute Tox. 3 Oral
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
法规信息
新产品
此项目有
Justin N Siemian et al.
British journal of pharmacology, 175(9), 1519-1534 (2018-02-17)
Although the antinociceptive efficacies of imidazoline I2 receptor agonists have been established, the exact post-receptor mechanisms remain unknown. This study tested the hypothesis that monoaminergic transmission is critical for I2 receptor agonist-induced antinociception. von Frey filaments were used to assess
J D Roth et al.
European journal of pharmacology, 373(2-3), 127-134 (1999-07-22)
Fenfluramine + phentermine was a widely used combination for weight loss. Fenfluramine and phentermine are believed to act via serotonin and catecholamines, respectively. To what extent these drugs interact has not been well-established. We compared the anorectic efficacy of a
Y X Wang et al.
The Journal of pharmacology and experimental therapeutics, 291(3), 1008-1016 (1999-11-24)
Fenfluramine is an indirect agonist of 5-hydroxytryptamine (5-HT) receptors that acts by evoking 5-HT release and blocking 5-HT reuptake in neuronal cells. The current study compared the antinociceptive properties of fenfluramine with those of the tricyclic antidepressants amitriptyline and desipramine