F8549
Fluprostenol
10 mg/mL in ethanol, 98%
别名:
(±)-16-(3-Trifluoromethylphenoxy)tetranorprostaglandin F2α
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关于此项目
经验公式（希尔记法）:
C23H29F3O6
CAS Number:
分子量:
458.47
EC 号:
MDL编号:
UNSPSC代码:
12352202
PubChem化学物质编号:
NACRES:
NA.77
质量水平
方案
98%
浓度
10 mg/mL in ethanol
储存温度
−20°C
SMILES字符串
O[C@H](COc1cccc(c1)C(F)(F)F)\C=C\[C@@H]2[C@@H](O)C[C@@H](O)[C@H]2C\C=C/CCCC(O)=O
InChI
1S/C23H29F3O6/c24-23(25,26)15-6-5-7-17(12-15)32-14-16(27)10-11-19-18(20(28)13-21(19)29)8-3-1-2-4-9-22(30)31/h1,3,5-7,10-12,16,18-21,27-29H,2,4,8-9,13-14H2,(H,30,31)/b3-1-,11-10+/t16-,18-,19-,20+,21-/m0/s1
InChI key
WWSWYXNVCBLWNZ-CHPNCWRZSA-N
应用
Fluprostenol has been used as a prostaglandin F (FP) receptor agonist to study its effects on osteoclast development. It has also been used as a prostaglandin F2α (PGF2α) receptor agonist to study its effects on mitogen-activated protein kinase (MAPK) signaling in rat aorta.
生化/生理作用
Fluprostenol is a selective prostaglandin F2-α (PGF2α) receptor or prostaglandin F (FP) receptor agonist.
警示用语：
Danger
危险声明
危险分类
Eye Irrit. 2 - Flam. Liq. 2
储存分类代码
3 - Flammable liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
法规信息
危险化学品
Tara L Aghaloo et al.
Journal of periodontology, 77(1), 21-30 (2006-04-04)
Parathyroid hormone (PTH) regulates osteoblast function by binding to the PTH receptor 1 (PTHR1) to activate downstream signaling to induce expression of primary response genes (PRGs), which affect various aspects of the osteoblast phenotype. We previously identified PTH-induced PRGs in
Hitoshi Kashiwagi et al.
Thrombosis and haemostasis, 119(8), 1311-1320 (2019-05-28)
Platelets play an important role in both physiological hemostasis and pathological thrombosis. Thromboxane (TX) A2 and prostaglandin (PG) I2 are well known as a potent stimulator and an inhibitor of platelet function, respectively. Recently, PGE2 has also been reported to
Potent luteolytic agents related to prostaglandin F2alpha.
M Dukes et al.
Nature, 250(464), 330-331 (1974-07-26)
Long Gao et al.
Animal reproduction science, 199, 30-39 (2018-10-21)
The endometrium of domestic animals has a remarkable capacity to self-repair. Prostaglandin F2α (PGF2α) is one of the major prostaglandins secreted from the endometrium. The role of PGF2α in endometrial repair, however, is still unknown. In the present study, it
Jon Riise et al.
European journal of pharmacology, 686(1-3), 66-73 (2012-05-02)
Prostanoid-modulatory approaches in heart failure patients have displayed effects which may seem to be mutually incompatible. Both treatment with prostanoids and inhibition of prostanoid synthesis have resulted in increased mortality in heart failure patients. Currently, it is unknown if prostanoids
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