F8549
Fluprostenol
10 mg/mL in ethanol, 98%
别名:
(±)-16-(3-Trifluoromethylphenoxy)tetranorprostaglandin F2α
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关于此项目
经验公式（希尔记法）:
C23H29F3O6
化学文摘社编号:
分子量:
458.47
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352202
EC Number:
200-578-6
MDL number:
Assay:
98%
Quality level:
InChI key
WWSWYXNVCBLWNZ-CHPNCWRZSA-N
InChI
1S/C23H29F3O6/c24-23(25,26)15-6-5-7-17(12-15)32-14-16(27)10-11-19-18(20(28)13-21(19)29)8-3-1-2-4-9-22(30)31/h1,3,5-7,10-12,16,18-21,27-29H,2,4,8-9,13-14H2,(H,30,31)/b3-1-,11-10+/t16-,18-,19-,20+,21-/m0/s1
SMILES string
O[C@H](COc1cccc(c1)C(F)(F)F)\C=C\[C@@H]2[C@@H](O)C[C@@H](O)[C@H]2C\C=C/CCCC(O)=O
assay
98%
concentration
10 mg/mL in ethanol
storage temp.
−20°C
Quality Level
Application
Fluprostenol has been used as a prostaglandin F (FP) receptor agonist to study its effects on osteoclast development. It has also been used as a prostaglandin F2α (PGF2α) receptor agonist to study its effects on mitogen-activated protein kinase (MAPK) signaling in rat aorta.
Biochem/physiol Actions
Fluprostenol is a selective prostaglandin F2-α (PGF2α) receptor or prostaglandin F (FP) receptor agonist.
signalword
Danger
hcodes
Hazard Classifications
Eye Irrit. 2 - Flam. Liq. 2
存储类别
3 - Flammable liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
法规信息
危险化学品
此项目有
Tara L Aghaloo et al.
Journal of periodontology, 77(1), 21-30 (2006-04-04)
Parathyroid hormone (PTH) regulates osteoblast function by binding to the PTH receptor 1 (PTHR1) to activate downstream signaling to induce expression of primary response genes (PRGs), which affect various aspects of the osteoblast phenotype. We previously identified PTH-induced PRGs in
Potent luteolytic agents related to prostaglandin F2alpha.
M Dukes et al.
Nature, 250(464), 330-331 (1974-07-26)
Maria Giovanna Sabbieti et al.
Cell and tissue research, 319(2), 267-278 (2005-01-18)
We have previously reported that prostaglandin F(2alpha) (PGF(2alpha)) and its selective agonist fluprostenol increase basic fibroblast growth factor (FGF-2) mRNA and protein production in osteoblastic Py1a cells. The present report extends our previous studies by showing that Py1a cells express
Jon Riise et al.
European journal of pharmacology, 686(1-3), 66-73 (2012-05-02)
Prostanoid-modulatory approaches in heart failure patients have displayed effects which may seem to be mutually incompatible. Both treatment with prostanoids and inhibition of prostanoid synthesis have resulted in increased mortality in heart failure patients. Currently, it is unknown if prostanoids
Hitoshi Kashiwagi et al.
Thrombosis and haemostasis, 119(8), 1311-1320 (2019-05-28)
Platelets play an important role in both physiological hemostasis and pathological thrombosis. Thromboxane (TX) A2 and prostaglandin (PG) I2 are well known as a potent stimulator and an inhibitor of platelet function, respectively. Recently, PGE2 has also been reported to
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