F8549
Fluprostenol
10 mg/mL in ethanol, 98%
别名:
(±)-16-(3-Trifluoromethylphenoxy)tetranorprostaglandin F2α
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关于此项目
经验公式（希尔记法）:
C23H29F3O6
化学文摘社编号:
分子量:
458.47
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352202
EC Number:
200-578-6
MDL number:
Assay:
98%
Quality level:
InChI key
WWSWYXNVCBLWNZ-CHPNCWRZSA-N
InChI
1S/C23H29F3O6/c24-23(25,26)15-6-5-7-17(12-15)32-14-16(27)10-11-19-18(20(28)13-21(19)29)8-3-1-2-4-9-22(30)31/h1,3,5-7,10-12,16,18-21,27-29H,2,4,8-9,13-14H2,(H,30,31)/b3-1-,11-10+/t16-,18-,19-,20+,21-/m0/s1
SMILES string
O[C@H](COc1cccc(c1)C(F)(F)F)\C=C\[C@@H]2[C@@H](O)C[C@@H](O)[C@H]2C\C=C/CCCC(O)=O
assay
98%
concentration
10 mg/mL in ethanol
storage temp.
−20°C
Quality Level
Application
Fluprostenol has been used as a prostaglandin F (FP) receptor agonist to study its effects on osteoclast development. It has also been used as a prostaglandin F2α (PGF2α) receptor agonist to study its effects on mitogen-activated protein kinase (MAPK) signaling in rat aorta.
Biochem/physiol Actions
Fluprostenol is a selective prostaglandin F2-α (PGF2α) receptor or prostaglandin F (FP) receptor agonist.
signalword
Danger
hcodes
Hazard Classifications
Eye Irrit. 2 - Flam. Liq. 2
存储类别
3 - Flammable liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
法规信息
危险化学品
此项目有
Clayton S Spada et al.
Experimental eye research, 75(2), 155-163 (2002-07-26)
Prostanoid analogs have recently been introduced into clinical use for the management of increased intraocular pressure (IOP). This class of compounds is known to exert effects on vascular components and some endogenous parent prostaglandins have been shown to alter regional
David Lindsey Soper et al.
Advances in experimental medicine and biology, 507, 303-307 (2003-04-01)
A series of prostaglandins selective for the human FP receptor have been synthesized and evaluated as potential therapeutics for the treatment of osteoporosis. The compounds proved to be potent (nanomolar binding affinity) and selective (> 100x) ligands for the human
Shuangyi Zhang et al.
Reproduction, fertility, and development, 29(11), 2195-2205 (2017-03-17)
The endometrium of domestic animals undergoes regular periods of regeneration and degeneration and exhibits a remarkable capacity for self-repair during the oestrous cycle. The endometrial growth pattern is also observed during in the implantation period and early pregnancy, but the
P M Camargo et al.
Journal of periodontology, 76(2), 303-309 (2005-06-25)
The prostaglandins (PG) E(2) and PGF(2alpha) are important cytokines in periodontal physiology and pathology. PGE(2) and PGF(2alpha) alter cell function by binding and activating the plasmamembrane G-protein-coupled PG receptors. In this study, we examined the PGE(2) and PGF(2alpha) effects on
H Kaneko et al.
Prostaglandins, leukotrienes, and essential fatty acids, 77(3-4), 181-186 (2007-10-24)
Prostaglandins (PGs) can act on both hematopoietic and osteoblastic lineages to enhance osteoclast formation. We examined PGE2 stimulated osteoclastogenesis in RAW 264.7 cells and the role of endogenous PGE2 in lipopolysaccharide (LPS) stimulated osteoclastogenesis. RANKL (1-100 ng/ml) increased formation of
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