Application
甲酸脱氢酶(FDH)用于大规模工业过程中的诊断。它用于生产非天然氨基酸,叔-L-亮氨酸,一些 HIV 蛋白酶和基质金属蛋白酶抑制剂的成分。
Biochem/physiol Actions
甲酸脱氢酶参与植物的应激反应并催化 NAD+ 还原为 NADH。
甲酸脱氢酶是来自酵母念珠菌(Candida boidinii)(CbFDH)的丰富酶,其在甲基营养微生物的能量供应和植物的应激反应中起重要作用。
Other Notes
在 β-NAD 存在下,pH7.6,37℃,一个单元每分钟将 1.0 μmole 的甲酸盐氧化成 CO2。
signalword
Danger
hcodes
pcodes
Hazard Classifications
Resp. Sens. 1
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
常规特殊物品
此项目有
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A Skelt
Nursing times, 84(4), 50-52 (1988-01-02)
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Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 17(5), 831-838 (2012-04-25)
Desulfovibrio spp. are sulfate-reducing organisms characterized by having multiple periplasmic hydrogenases and formate dehydrogenases (FDHs). In contrast to enzymes in most bacteria, these enzymes do not reduce directly the quinone pool, but transfer electrons to soluble cytochromes c. Several studies
Yoshihiro Ojima et al.
Biotechnology letters, 34(5), 889-893 (2012-01-05)
Pyruvate was produced from glucose by Escherichia coli BW25113 that contained formate dehydrogenase (FDH) from Mycobacterium vaccae. In aerobic shake-flask culture (K (L) a = 4.9 min(-1)), the recombinant strain produced 6.7 g pyruvate l(-1) after 24 h with 4 g sodium formate l(-1) and a yield of
Dmitry K Nilov et al.
Journal of biomolecular structure & dynamics, 30(2), 170-179 (2012-06-19)
The formation of the reactive enzyme-substrate complex of formate dehydrogenase has been investigated by molecular dynamics techniques accounting for different conformational states of the enzyme. Simulations revealed that the transport of substrate to the active site through the substrate channel
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