F9304
Anti-FBI-1/Pokemon antibody produced in rabbit
IgG fraction of antiserum, buffered aqueous solution
别名:
Anti-FBI-1, Anti-LRF, Anti-POK Erythroid Myeloid Ontogenic Factor, Anti-ZBTB7, Anti-Zinc Finger- and BTB Domain-containing Protein 7
biological source
rabbit
conjugate
unconjugated
antibody form
IgG fraction of antiserum
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 75 kDa
species reactivity
human
technique(s)
immunoprecipitation (IP): 2-4 μL using A431 cell lysates, western blot (chemiluminescent): 1:4,000-1:6,000 using K-562 lysates
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
Gene Information
human ... ZBTB7A(51341)
Immunogen
synthetic peptide corresponding to amino acids 544-560 of human FBI-1/Pokemon, conjugated to KLH.
Application
Anti-FBI-1/Pokemon antibody is suitable for immunoprecipitation at a concentration of 2-4μL using A431 cell lysates and western blot (chemiluminescent) at a dilution of 1:4,000-1:6,000 using K-562 lysates.
Biochem/physiol Actions
FBI-1/Pokemon is a BTB/POZ containing zinc-finger protein. It is predominantly expressed in a subset of T-cell lymphoma and B-cell lymphomas. It is also found in breast, lung, colon, prostate, and bladder carcinomas. It has capacity to bind the HIV-inducer of short transcripts (IST), thus called FBI-1. It was identified as a critical factor in oncogenesis and was called Pokemon (POK erythroid myeloid ontogenic factor). By binding to the tumor suppressor gene ARF, the Pokemon exerts its oncogenic activity.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, and 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
12 - Non Combustible Liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
新产品
此项目有
Takahiro Maeda et al.
Cancer research, 65(19), 8575-8578 (2005-10-06)
Learning how critical cell regulatory pathways are controlled may lead to new opportunities for cancer treatment. We recently identified the transcription factor Pokemon as a central regulator of the important tumor suppressor ARF. Pokemon is overexpressed in multiple human cancers
FBI-1, a factor that binds to the HIV-1 inducer of short transcripts (IST), is a POZ domain protein.
D J Morrison et al.
Nucleic acids research, 27(5), 1251-1262 (1999-02-12)
The HIV-1 promoter directs the synthesis of two classes of transcripts, short, non-polyadenylated transcripts and full-length, polyadenylated transcripts. The synthesis of short transcripts is activated by a bipartite DNA element, the inducer of short transcripts or IST, located downstream of
J M Davies et al.
Oncogene, 18(2), 365-375 (1999-02-02)
BTB/POZ-domain C2H2 zinc(Zn)-finger proteins are encoded by a subfamily of genes related to the Drosophila gap gene krüppel. To date, two such proteins, PLZF and LAZ-3/BCL-6, have been implicated in oncogenesis. We have now identified a new member of this
Takahiro Maeda et al.
Nature, 433(7023), 278-285 (2005-01-22)
Aberrant transcriptional repression through chromatin remodelling and histone deacetylation has been postulated to represent a driving force underlying tumorigenesis because histone deacetylase inhibitors have been found to be effective in cancer treatment. However, the molecular mechanisms by which transcriptional derepression
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