F9304
Anti-FBI-1/Pokemon antibody produced in rabbit
IgG fraction of antiserum, buffered aqueous solution
别名:
Anti-FBI-1, Anti-LRF, Anti-POK Erythroid Myeloid Ontogenic Factor, Anti-ZBTB7, Anti-Zinc Finger- and BTB Domain-containing Protein 7
生物来源
rabbit
偶联物
unconjugated
抗体形式
IgG fraction of antiserum
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
antigen 75 kDa
种属反应性
human
技术
immunoprecipitation (IP): 2-4 μL using A431 cell lysates
western blot (chemiluminescent): 1:4,000-1:6,000 using K-562 lysates
UniProt登记号
运输
dry ice
储存温度
−20°C
基因信息
human ... ZBTB7A(51341)
免疫原
synthetic peptide corresponding to amino acids 544-560 of human FBI-1/Pokemon, conjugated to KLH.
应用
Anti-FBI-1/Pokemon antibody is suitable for immunoprecipitation at a concentration of 2-4μL using A431 cell lysates and western blot (chemiluminescent) at a dilution of 1:4,000-1:6,000 using K-562 lysates.
生化/生理作用
FBI-1/Pokemon is a BTB/POZ containing zinc-finger protein. It is predominantly expressed in a subset of T-cell lymphoma and B-cell lymphomas. It is also found in breast, lung, colon, prostate, and bladder carcinomas. It has capacity to bind the HIV-inducer of short transcripts (IST), thus called FBI-1. It was identified as a critical factor in oncogenesis and was called Pokemon (POK erythroid myeloid ontogenic factor). By binding to the tumor suppressor gene ARF, the Pokemon exerts its oncogenic activity.
外形
Solution in 0.01 M phosphate buffered saline, pH 7.4, and 15 mM sodium azide.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
12 - Non Combustible Liquids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
新产品
此项目有
Takahiro Maeda et al.
Cancer research, 65(19), 8575-8578 (2005-10-06)
Learning how critical cell regulatory pathways are controlled may lead to new opportunities for cancer treatment. We recently identified the transcription factor Pokemon as a central regulator of the important tumor suppressor ARF. Pokemon is overexpressed in multiple human cancers
J M Davies et al.
Oncogene, 18(2), 365-375 (1999-02-02)
BTB/POZ-domain C2H2 zinc(Zn)-finger proteins are encoded by a subfamily of genes related to the Drosophila gap gene krüppel. To date, two such proteins, PLZF and LAZ-3/BCL-6, have been implicated in oncogenesis. We have now identified a new member of this
Takahiro Maeda et al.
Nature, 433(7023), 278-285 (2005-01-22)
Aberrant transcriptional repression through chromatin remodelling and histone deacetylation has been postulated to represent a driving force underlying tumorigenesis because histone deacetylase inhibitors have been found to be effective in cancer treatment. However, the molecular mechanisms by which transcriptional derepression
FBI-1, a factor that binds to the HIV-1 inducer of short transcripts (IST), is a POZ domain protein.
D J Morrison et al.
Nucleic acids research, 27(5), 1251-1262 (1999-02-12)
The HIV-1 promoter directs the synthesis of two classes of transcripts, short, non-polyadenylated transcripts and full-length, polyadenylated transcripts. The synthesis of short transcripts is activated by a bipartite DNA element, the inducer of short transcripts or IST, located downstream of
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