F9424
Fibroblast Growth Factor Receptor-2α (IIIb)/Fc Chimera human
>90% (SDS-PAGE), recombinant, expressed in baculovirus infected Sf21 cells, lyophilized powder
别名:
FGFR-2α (IIIb)/Fc
biological source
human
recombinant
expressed in baculovirus infected Sf21 cells
assay
>90% (SDS-PAGE)
form
lyophilized powder
potency
1-3 ng/mL ED50
mol wt
monomer calculated mol wt 66 kDa, ~100 kDa by SDS-PAGE (reducing)
storage condition
avoid repeated freeze/thaw cycles (Do not store in a frost-free freezer.)
impurities
<1 EU/μg Endotoxin level (LAL test)
UniProt accession no.
storage temp.
−20°C
Gene Information
human ... FGFR2(2263)
General description
FGFR2 (fibroblast growth factor receptor 2) is a member of the tyrosine kinase receptor family called FGFR. This gene is localized to human chromosome 10q26, and is composed of 2 exons.
Its ligand-binding domain in present in its extracellular region, which is composed of three immunoglobulin (Ig)-like domains. It spans the membrane once, and its tyrosine kinase domain is localized to its intracellular region. Alternative splicing of this gene gives rise to two isoforms- epithelial (FGFR2IIIb) and mesenchymal (FGFR2IIIc).
Its ligand-binding domain in present in its extracellular region, which is composed of three immunoglobulin (Ig)-like domains. It spans the membrane once, and its tyrosine kinase domain is localized to its intracellular region. Alternative splicing of this gene gives rise to two isoforms- epithelial (FGFR2IIIb) and mesenchymal (FGFR2IIIc).
Biochem/physiol Actions
FGFR2 (fibroblast growth factor receptor 2) facilitates tumor growth, invasiveness, metastasis and angiogenesis. It plays an essential role in the development of mammary glands, and its expression is elevated in breast cancers. Studies in North Indian population suggest that polymorphisms in this gene might be linked to susceptibility to breast cancer. It is anti-apoptotic in nature, and suppresses p53-mediated apoptosis, by inducing the elevation of MDM2 levels. Mutations in this gene are linked to mild Crouzon syndrome and craniosynostosis.
Physical form
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline
Analysis Note
The bioactivity is measured by its ability to inhibit human fibroblast growth factor acidic-dependent proliferation of NR6 cells.
Other Notes
Human recombinant FGFR-2α (IIIb)/Fc is a disulfide-linked homodimeric protein. As a result of glycosylation, it migrates as an approximately 100 kDa protein.
法规信息
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Aimee L Fenwick et al.
BMC medical genetics, 15, 95-95 (2014-09-02)
Mutations of fibroblast growth factor receptor 2 (FGFR2) account for a higher proportion of genetic cases of craniosynostosis than any other gene, and are associated with a wide spectrum of severity of clinical problems. Many of these mutations are highly
Sarah Siddiqui et al.
PloS one, 9(10), e110426-e110426 (2014-10-22)
Genome-Wide Association Studies (GWAS) have identified Fibroblast growth factor receptor 2 (FGFR2) as a candidate gene for breast cancer with single nucleotide polymorphisms (SNPs) located in intron 2 region as the susceptibility loci strongly associated with the risk. However, replicate
Zahra Saadatian et al.
Asian Pacific journal of cancer prevention : APJCP, 15(18), 7955-7958 (2014-10-09)
Breast cancer is the most common cancer among women in the world. In Iran, the incidence of breast cancer is on the increase. We here studied the association of rs1219648 in FGFR2 and rs1042522 in TP53 and their interaction in
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