G012
γ-氨基丁酸
别名:
3-羧丙胺, 4-氨基丁酸, GABA, 哌啶酸, 氨酪酸
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关于此项目
线性分子式:
NH2(CH2)3COOH
化学文摘社编号:
分子量:
103.12
EC Number:
200-258-6
UNSPSC Code:
12352200
MDL number:
Beilstein/REAXYS Number:
906818
InChI
1S/C4H9NO2/c5-3-1-2-4(6)7/h1-3,5H2,(H,6,7)
InChI key
BTCSSZJGUNDROE-UHFFFAOYSA-N
SMILES string
NCCCC(O)=O
mp
195 °C (dec.) (lit.)
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Biochem/physiol Actions
大脑中的主要抑制性神经递质；GABAA 和 GABAB 受体激动剂；增加 Cl− 的传导性。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
此项目有
Changho Choi et al.
Magnetic resonance in medicine, 54(2), 272-279 (2005-07-21)
An optimized single-shot proton double-quantum (DQ) filter for the quantification of gamma-aminobutyric acid (GABA) levels in human brain is reported. It is demonstrated that creation of DQ coherences following dual-resonance-selective refocusing gives a theoretical editing efficiency of 50% for the
Claudio Giachino et al.
Development (Cambridge, England), 141(1), 83-90 (2013-11-29)
Adult neurogenesis is tightly regulated through the interaction of neural stem/progenitor cells (NSCs) with their niche. Neurotransmitters, including GABA activation of GABAA receptor ion channels, are important niche signals. We show that adult mouse hippocampal NSCs and their progeny express
Vincent Paille et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(22), 9353-9363 (2013-05-31)
The spike-timing-dependent plasticity (STDP), a synaptic learning rule for encoding learning and memory, relies on relative timing of neuronal activity on either side of the synapse. GABAergic signaling has been shown to control neuronal excitability and consequently the spike timing
Richard P Allen et al.
The New England journal of medicine, 370(7), 621-631 (2014-02-14)
Dopaminergic medications relieve symptoms of the restless legs syndrome (RLS) but have the potential to cause iatrogenic worsening (augmentation) of RLS with long-term treatment. Pregabalin may be an effective alternative. In this 52-week, randomized, double-blind trial, we assessed efficacy and
T Clayton et al.
Current medicinal chemistry, 14(26), 2755-2775 (2007-11-30)
A successful unified pharmacophore/receptor model which has guided the synthesis of subtype selective compounds is reviewed in light of recent developments both in ligand synthesis and structural studies of the binding site itself. The evaluation of experimental data in combination
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