G0419
GR 55562 dihydrobromide
>97% (HPLC), powder
别名:
3-[3-(Dimethylamino)propyl]-4-hydroxy-N-[4-(4-pyridinyl)phenyl]benzamide dihydrobromide
描述
Store tightly sealed with desiccant.
方案
>97% (HPLC)
表单
powder
颜色
light yellow
溶解性
H2O: ~12 mg/mL (with mixing)
储存温度
2-8°C
InChI
1S/C23H25N3O2.ClH/c1-26(2)15-3-4-19-16-20(7-10-22(19)27)23(28)25-21-8-5-17(6-9-21)18-11-13-24-14-12-18;/h5-14,16,27H,3-4,15H2,1-2H3,(H,25,28);1H
InChI key
NUDSRNNZTVHCKY-UHFFFAOYSA-N
生化/生理作用
5-HT1B/5-HT1D serotonin receptor antagonist
特点和优势
This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
法律信息
Sold for research purposes under agreement from GlaxoSmithKline
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
Ji-Hyun Kim et al.
Pharmacology, biochemistry, and behavior, 87(1), 41-47 (2007-05-05)
The present study was undertaken to investigate the antidepressant-like effects of the methylene chloride fraction of Albizzia julibrissin (MCAJ) using a tail suspension test in mice. MCAJ was orally administered at 50, 100, or 200 mg/kg to mice, 1 h
E Przegaliński et al.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 53(3), 383-394 (2002-10-09)
The present study was designed to examine the effect of 5-HT1B receptor ligands microinjected into the subregions of the nucleus accumbens (the shell and the core) on the locomotor hyperactivity induced by cocaine in rats. Male Wistar rats were implanted
Edmund Przegaliński et al.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 12(5), 387-396 (2002-09-05)
The present study was designed to find out whether 5-HT(1B) receptors located in subareas of the nucleus accumbens played a role in cocaine sensitization in rats, and whether pharmacological activation of these receptors could modify this drug effect. Male Wistar
M Filip et al.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 52(2), 249-263 (2001-07-17)
Mesolimbic dopamine pathways play a critical role in the behavioural effects of cocaine in rodents. Nonetheless, research has also demonstrated involvement of 5-hydroxytryptamine (5-HT; serotonin) transmission in these effects. The present study investigated the ability of selective 5-HT1B receptor ligands
M R MacLean et al.
British journal of pharmacology, 119(2), 277-282 (1996-09-01)
1. The 5-hydroxytryptamine (5-HT) receptors mediating contraction of human isolated pulmonary artery rings were investigated. Responses to the agonists 5-carboximidotryptamine (5-CT, non-selective 5-HT1 agonist), sumatriptan (5-HT1D-like receptor agonist), 5-HT and 8-hydroxy-2-(di-n-propylamino)-tetralin (8-OH-DPAT, 5-HT1A receptor agonist) were studied. Responses to 5-HT
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