产品名称
D-(+)-半乳糖胺 盐酸盐, ≥99% (HPLC)
InChI key
CBOJBBMQJBVCMW-NQZVPSPJSA-N
InChI
1S/C6H13NO5.ClH/c7-3(1-8)5(11)6(12)4(10)2-9;/h1,3-6,9-12H,2,7H2;1H/t3-,4+,5+,6-;/m0./s1
SMILES string
Cl.N[C@@H](C=O)[C@@H](O)[C@@H](O)[C@H](O)CO
assay
≥99% (HPLC)
form
powder
technique(s)
HPLC: suitable
impurities
≤0.5% Glucosamine (HPAE)
color
white to off-white
mp
172-180 °C
solubility
H2O: 50 mg/mL, clear to slightly hazy, colorless to very faintly yellow
storage temp.
room temp
Quality Level
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Application
D-(+)-半乳糖盐酸盐已用于：
- 甘露聚糖结合凝集素（MBL）与改性云母表面的表面结合
- 腹腔注射前的无菌磷酸盐缓冲液（PBS）中
- 小鼠中产生原发性骨髓来源的巨噬细胞（BMDM）
D-(+)-半乳糖胺（D-软骨胺）联合脂多糖（LPS）已用于诱导急性肝衰竭模型（LPS/D-GALN诱导肝损伤、肝炎）的治疗研究，以寻找新药。
Biochem/physiol Actions
半乳糖胺（Gal）通过细胞坏死和凋亡诱导肝细胞死亡。它通过产生尿苷二磷酸己糖胺来阻止肝RNA的产生。D-半乳糖胺可降低细胞内尿嘧啶核苷酸库，进而阻止RNA和蛋白质的产生。
General description
D-半乳糖胺（d-GalN）是一种特异性肝毒剂，尤其可在肝细胞内代谢。它是一种源自半乳糖的6碳氨基糖。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Xing Lin et al.
Biological & pharmaceutical bulletin, 37(4), 625-632 (2014-05-13)
This study examined the effect of genistein from Hydrocotyle sibthorpioides on lipopolysaccharide (LPS)/D-galactosamine (D-GalN)-induced acute hepatic failure. Compared to the model control, genistein treatment significantly protected against LPS/D-GalN-induced liver injury, as evidenced by the decrease in serum alanine and aspartate
Kaicen Wang et al.
mSphere, 5(1) (2020-01-31)
Acute liver failure is a severe liver disorder that poses considerable global challenges. Previous studies on Bifidobacterium longum R0175 have mainly focused on its psychotropic functions. The current research focused on the protective efficacy of B. longum R0175 against acute
Aoxiang Zhuge et al.
Applied microbiology and biotechnology, 104(17), 7437-7455 (2020-07-16)
Acute liver failure is a clinical emergency associated with high mortality. Accumulating evidence indicates that gut microbiota participates in the progression of liver injury, and preventive therapies based on altering gut microbiota are of great interest. Previous studies demonstrated that
Yating Li et al.
Applied microbiology and biotechnology, 103(1), 375-393 (2018-10-23)
Acute liver failure is a drastic, unpredictable clinical syndrome with high mortality. Various preventive and adjuvant therapies based on modulating the gut flora have been proposed for hepatic injury. We aimed to explore the preventive and therapeutic effects of Bifidobacterium
Yinhong Zhu et al.
International immunopharmacology, 72, 131-137 (2019-04-14)
Saikosaponin a (SSa), one of the major active components of Bupleurum falcatum, has antioxidant and anti-inflammatory pharmacological properties. However, the effects of SSa on liver injury have not been reported. In the present study, we evaluated the protective effects and
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