G0769
Growth Hormone Releasing Factor porcine
≥97% (HPLC), powder, synthetic
别名:
GRF
biological source
synthetic
assay
≥97% (HPLC)
form
powder
UniProt accession no.
storage temp.
−20°C
Gene Information
human ... GHRHR(397100)
General description
Growth hormone releasing factor (GHRF) is a hypothalamus-secreted peptide composed of 40-44 amino acids. This protein is expressed by organs such as, ovaries, testis and placenta, and cells such as, lymphocytes.
Application
Growth hormone releasing factor (GHRF) procine has been used for GHRH challenge test in pigs, 48hrs post- intravenous glucose tolerance test (IVGTT).
Biochem/physiol Actions
Growth hormone releasing factor (GHRF) binds to GHRF receptors in the anterior pituitary, leading to the production and release of GH (growth hormone). GH induces the production of the mitogen insulin-like growth factor-I in the liver. In peripheral organs and cancer, GHRF has a paracrine/autocrine function. It is abnormally expressed in gynecological tumors, pancreatic, lung and prostate cancer. This protein might be responsible for pathogenesis of endometrioid type of endometrial cancers. It is essential for the amplification of GH secretion during night time.
Hypothalamic peptide that stimulates release of somatotropin from anterior pituitary
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
Ioulia Chatzistamou et al.
European journal of endocrinology, 147(3), 381-386 (2002-09-06)
Hypothalamic GH-releasing hormone (GHRH) regulates GH release from the pituitary, but an ectopic production of GHRH has been detected in various non-hypothalamic tissues, especially cancers. To investigate whether endometrial tumors produce GHRH. Twenty-four endometrioid, three serous papillary (SP), three mixed
E K Amoikon et al.
Journal of animal science, 73(4), 1123-1130 (1995-04-01)
Two experiments were conducted to evaluate the effect of Cr as Cr tripicolinate (CrPic) on growth, glucose tolerance, insulin sensitivity, plasma metabolites, and growth hormone (GH) in pigs. Pigs were fed a control diet or a diet supplemented with 200
Stacy K Jessup et al.
European journal of endocrinology, 151(5), 561-566 (2004-11-13)
A temporal association between non-rapid eye movement (NREM) sleep stages 3 and 4 and nocturnal augmentation of GH release was found long ago, yet the precise mechanism for this association has not been identified. It has been shown, however that
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