G1043
Guanfacine hydrochloride
≥98% (HPLC)
别名:
N (Aminoiminomethyl)-2,6-dichlorobenzeneacetamide
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关于此项目
经验公式（希尔记法）:
C9H9Cl2N3O · HCl
化学文摘社编号:
分子量:
282.55
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥98% (HPLC)
Quality level:
InChI key
DGFYECXYGUIODH-UHFFFAOYSA-N
SMILES string
Cl.NC(=N)NC(=O)Cc1c(Cl)cccc1Cl
InChI
1S/C9H9Cl2N3O.ClH/c10-6-2-1-3-7(11)5(6)4-8(15)14-9(12)13;/h1-3H,4H2,(H4,12,13,14,15);1H
assay
≥98% (HPLC)
color
white
solubility
H2O: soluble 12 mg/mL at 60 °C
originator
Promius
Quality Level
Gene Information
human ... ADRA2A(150), ADRA2B(151), ADRA2C(152)
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Application
Guanfacine hydrochloride has been used as an α2A adrenoceptor agonist to test its protective effect on hypobaric hypoxia (HH) and in rat brain to measure blood oxygenation level dependent (BOLD) response.
Biochem/physiol Actions
α-2 noradrenergic receptor agonist.
Guanfacine stimulates the brain postsynaptic α2 adrenergic receptor (AR) and mediates the prefrontal cortical (PFC) neuronal regulation and strengthens their network. Guanfacine improves the density of neuronal dendrites and is useful in treating neuropsychiatric disorders. It modulates the synaptic and cytoskeletal proteins expression in prefrontal cortical (PFC) neurons and may improve hypobaric hypoxia (HH) induced PFC dysfunctions. Guanfacine enhances cognitive function and is recommended for attention deficit hyperactivity disorder (ADHD) therapy.
Features and Benefits
This compound was developed by Promius. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Sophie Duong et al.
Expert opinion on drug metabolism & toxicology, 8(5), 543-552 (2012-03-15)
Pharmacotherapy is frequently used to treat symptoms of attention-deficit/hyperactivity disorder (ADHD), the most common neurobehavioral disorder of childhood. The typically prescribed agents for ADHD have varying durations of effect and degrees of efficacy. The broad range of pharmacological treatments available
Guanfacine produces differential effects in frontal cortex compared with striatum: assessed by phMRI BOLD contrast
Easton N, et al.
Psychopharmacology, 189(3), 369-385 (2006)
Once-daily treatment of ADHD with guanfacine: patient implications
Strange BC
Neuropsychiatric Disease and Treatment, 4(3), 499-499 (2008)
Guanfacine promotes neuronal survival in medial prefrontal cortex under hypobaric hypoxia
Kauser H, et al.
Brain Research, 1636, 152-160 (2016)
Yuanyuan Li et al.
Bioanalysis, 4(12), 1445-1456 (2012-07-17)
Direct analysis of dried blood spot (DBS) samples was investigated using a prototype semi-automated robotic device that allows the direct elution of sample spots from a DBS paper card to an online SPE cartridge. The eluted SPE samples were analyzed
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